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MIB1

GENERAL INFORMATION

Gene name

 MIB1

Gene description

 Mindbomb E3 ubiquitin protein ligase 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in many tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA019100 , CAB037044
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MIB1 (HGNC Symbol)

Synonyms

 DIP-1, KIAA1323, MIB, ZZANK2, ZZZ6

Description

 Mindbomb E3 ubiquitin protein ligase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]

Chromosome

 18

Cytoband

 q11.2

Chromosome location (bp)

 21704957 - 21870957

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101752 (version 83.38)

Entrez gene

 57534

UniProt

 Q86YT6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86YT6

Antibodypedia

 MIB1 antibodies

PROTEIN BROWSER
MIB1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MIB1-001
ENSP00000261537
ENST00000261537
Q86YT6 [Direct mapping]
E3 ubiquitin-protein ligase MIB1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001568 [blood vessel development]
GO:0001701 [in utero embryonic development]
GO:0001756 [somitogenesis]
GO:0001841 [neural tube formation]
GO:0001947 [heart looping]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008270 [zinc ion binding]
GO:0014069 [postsynaptic density]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031410 [cytoplasmic vesicle]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045807 [positive regulation of endocytosis]
GO:0046872 [metal ion binding]
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 1006 aa
110.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.