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MID1

CANCER ATLAS

Gene description

 Midline 1

Protein class

 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003715

GENE INFORMATION

Gene name

 MID1 (HGNC Symbol)

Synonyms

 FXY, OS, RNF59, TRIM18

Description

 Midline 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing; however, the full-length nature of some of the variants has not been determined. [provided by RefSeq, Jul 2010]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 10445310 - 10833654

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101871 (version 83.38)

Entrez gene

 4281

UniProt

 O15344 (UniProt - Evidence at protein level)

neXtProt

 NX_O15344

Antibodypedia

 MID1 antibodies

PROTEIN BROWSER
«
MID1-001
MID1-002
MID1-003
MID1-004
MID1-005
MID1-006
MID1-007
MID1-201
MID1-202
MID1-203
MID1-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MID1-001
ENSP00000370162
ENST00000380785
O15344 [Direct mapping]
E3 ubiquitin-protein ligase Midline-1
A0A024RBV4 [Target identity:100%; Query identity:100%]
Midline 1 (Opitz/BBB syndrome), isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0007389 [pattern specification process]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0035372 [protein localization to microtubule]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051219 [phosphoprotein binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
Show all
 667 aa
75.3 kDa 		No 0
MID1-002
ENSP00000387771
ENST00000423614
C9JZJ7 [Direct mapping]
E3 ubiquitin-protein ligase Midline-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
Show all
 197 aa
22.1 kDa 		No 0
MID1-003
ENSP00000370156
ENST00000380779
O15344 [Direct mapping]
E3 ubiquitin-protein ligase Midline-1
A0A024RBV4 [Target identity:100%; Query identity:100%]
Midline 1 (Opitz/BBB syndrome), isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0007389 [pattern specification process]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0035372 [protein localization to microtubule]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051219 [phosphoprotein binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
Show all
 667 aa
75.3 kDa 		No 0
MID1-004
ENSP00000391154
ENST00000413894
C9J453 [Direct mapping]
E3 ubiquitin-protein ligase Midline-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
Show all
 483 aa
54.5 kDa 		No 0
MID1-005
ENSP00000370164
ENST00000380787
O15344 [Direct mapping]
E3 ubiquitin-protein ligase Midline-1
A0A024RBV4 [Target identity:100%; Query identity:100%]
Midline 1 (Opitz/BBB syndrome), isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0007389 [pattern specification process]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0035372 [protein localization to microtubule]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051219 [phosphoprotein binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
Show all
 667 aa
75.3 kDa 		No 0
MID1-006
ENSP00000370157
ENST00000380780
O15344 [Direct mapping]
E3 ubiquitin-protein ligase Midline-1
A0A024RBV4 [Target identity:100%; Query identity:100%]
Midline 1 (Opitz/BBB syndrome), isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0007389 [pattern specification process]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0035372 [protein localization to microtubule]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051219 [phosphoprotein binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
Show all
 667 aa
75.3 kDa 		No 0
MID1-007
ENSP00000370159
ENST00000380782
O15344 [Direct mapping]
E3 ubiquitin-protein ligase Midline-1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0007389 [pattern specification process]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0035372 [protein localization to microtubule]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051219 [phosphoprotein binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
Show all
 552 aa
62.3 kDa 		No 0
MID1-201
ENSP00000312678
ENST00000317552
O15344 [Direct mapping]
E3 ubiquitin-protein ligase Midline-1
A0A024RBV4 [Target identity:100%; Query identity:100%]
Midline 1 (Opitz/BBB syndrome), isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007389 [pattern specification process]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0016874 [ligase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0035372 [protein localization to microtubule]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051219 [phosphoprotein binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
Show all
 667 aa
75.3 kDa 		No 0
MID1-202
ENSP00000414521
ENST00000453318
O15344 [Direct mapping]
E3 ubiquitin-protein ligase Midline-1
A0A024RBV4 [Target identity:100%; Query identity:100%]
Midline 1 (Opitz/BBB syndrome), isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0007389 [pattern specification process]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0035372 [protein localization to microtubule]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051219 [phosphoprotein binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
Show all
 667 aa
75.3 kDa 		No 0
MID1-203
ENSP00000483707
ENST00000610939
A0A087X0X0 [Direct mapping]
E3 ubiquitin-protein ligase Midline-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
Show all
 228 aa
25.7 kDa 		No 0
MID1-204
ENSP00000484712
ENST00000616003
A0A087X255 [Direct mapping]
E3 ubiquitin-protein ligase Midline-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
 540 aa
61.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.