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SUV39H1

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GENERAL INFORMATION

Gene name

 SUV39H1

Gene description

 Suppressor of variegation 3-9 homolog 1 (Drosophila)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SUV39H1 (HGNC Symbol)

Synonyms

 KMT1A, SUV39H

Description

 Suppressor of variegation 3-9 homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48695554 - 48709012

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101945 (version 83.38)

Entrez gene

 6839

UniProt

 O43463 (UniProt - Evidence at protein level)

neXtProt

 NX_O43463

Antibodypedia

 SUV39H1 antibodies

PROTEIN BROWSER
SUV39H1-001
SUV39H1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SUV39H1-001
ENSP00000365877
ENST00000376687
O43463 [Direct mapping]
Histone-lysine N-methyltransferase SUV39H1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000183 [chromatin silencing at rDNA]
GO:0000775 [chromosome, centromeric region]
GO:0000792 [heterochromatin]
GO:0000794 [condensed nuclear chromosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005652 [nuclear lamina]
GO:0005654 [nucleoplasm]
GO:0005677 [chromatin silencing complex]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006364 [rRNA processing]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0008270 [zinc ion binding]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0030154 [cell differentiation]
GO:0033553 [rDNA heterochromatin]
GO:0034968 [histone lysine methylation]
GO:0036123 [histone H3-K9 dimethylation]
GO:0036124 [histone H3-K9 trimethylation]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042054 [histone methyltransferase activity]
GO:0042754 [negative regulation of circadian rhythm]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046974 [histone methyltransferase activity (H3-K9 specific)]
GO:0047485 [protein N-terminus binding]
GO:0048511 [rhythmic process]
GO:0071456 [cellular response to hypoxia]
Show all
 412 aa
47.9 kDa 		No 0
SUV39H1-201
ENSP00000337976
ENST00000337852
O43463 [Direct mapping]
Histone-lysine N-methyltransferase SUV39H1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000183 [chromatin silencing at rDNA]
GO:0000775 [chromosome, centromeric region]
GO:0000792 [heterochromatin]
GO:0000794 [condensed nuclear chromosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005652 [nuclear lamina]
GO:0005654 [nucleoplasm]
GO:0005677 [chromatin silencing complex]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006364 [rRNA processing]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0008270 [zinc ion binding]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0030154 [cell differentiation]
GO:0033553 [rDNA heterochromatin]
GO:0034968 [histone lysine methylation]
GO:0036123 [histone H3-K9 dimethylation]
GO:0036124 [histone H3-K9 trimethylation]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042054 [histone methyltransferase activity]
GO:0042754 [negative regulation of circadian rhythm]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046974 [histone methyltransferase activity (H3-K9 specific)]
GO:0047485 [protein N-terminus binding]
GO:0048511 [rhythmic process]
GO:0051567 [histone H3-K9 methylation]
GO:0071456 [cellular response to hypoxia]
Show all
 423 aa
49.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.