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Weak to moderate, granular cytoplasmic immunoreactivity was observed in most melanomas, thyroid and colorectal cancers along with few endometrial, breast, pancreatic and liver cancers. Remaining cancer tissues were weakly stained or generally negative.
GENE INFORMATION
Gene name
PAGE4 (HGNC Symbol)
Synonyms
CT16.7, GAGEC1, PAGE-4
Description
P antigen family, member 4 (prostate associated) (HGNC Symbol)
Entrez gene summary
This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. [provided by RefSeq, Aug 2013]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
