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GLRA2

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GENERAL INFORMATION

Gene name

 GLRA2

Gene description

 Glycine receptor, alpha 2

Protein class

 FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (AN3-CA)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (AN3-CA)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GLRA2 (HGNC Symbol)

Synonyms

 GLR

Description

 Glycine receptor, alpha 2 (HGNC Symbol)

Entrez gene summary

 The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 14529298 - 14731812

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101958 (version 83.38)

Entrez gene

 2742

UniProt

 P23416 (UniProt - Evidence at transcript level)

neXtProt

 NX_P23416

Antibodypedia

 GLRA2 antibodies

PROTEIN BROWSER
GLRA2-001
GLRA2-002
GLRA2-003
GLRA2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GLRA2-001
ENSP00000218075
ENST00000218075
P23416 [Direct mapping]
Glycine receptor subunit alpha-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007218 [neuropeptide signaling pathway]
GO:0007416 [synapse assembly]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016594 [glycine binding]
GO:0016934 [extracellular-glycine-gated chloride channel activity]
GO:0021510 [spinal cord development]
GO:0022824 [transmitter-gated ion channel activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043200 [response to amino acid]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0060012 [synaptic transmission, glycinergic]
GO:1902476 [chloride transmembrane transport]
Show all
 452 aa
52 kDa 		Yes 4
GLRA2-002
ENSP00000391606
ENST00000415367
C9JBL4 [Direct mapping]
Glycine receptor subunit alpha-2
Show all
Predicted intracellular proteins
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016594 [glycine binding]
GO:0022824 [transmitter-gated ion channel activity]
GO:0034220 [ion transmembrane transport]
Show all
 215 aa
24.7 kDa 		No 0
GLRA2-003
ENSP00000347123
ENST00000355020
P23416 [Direct mapping]
Glycine receptor subunit alpha-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007218 [neuropeptide signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016594 [glycine binding]
GO:0016934 [extracellular-glycine-gated chloride channel activity]
GO:0022824 [transmitter-gated ion channel activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043200 [response to amino acid]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0060012 [synaptic transmission, glycinergic]
GO:1902476 [chloride transmembrane transport]
Show all
 452 aa
52 kDa 		Yes 4
GLRA2-201
ENSP00000387756
ENST00000443437
P23416 [Direct mapping]
Glycine receptor subunit alpha-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007218 [neuropeptide signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016594 [glycine binding]
GO:0016934 [extracellular-glycine-gated chloride channel activity]
GO:0022824 [transmitter-gated ion channel activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043200 [response to amino acid]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0060012 [synaptic transmission, glycinergic]
GO:1902476 [chloride transmembrane transport]
Show all
 363 aa
42 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.