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MCF2

GENERAL INFORMATION

Gene name

 MCF2

Gene description

 MCF.2 cell line derived transforming sequence

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (adrenal gland, testis, seminal vesicle, epididymis, ovary, cerebral cortex)
GTEx:Tissue enhanced (adrenal gland, testis)
FANTOM5:Tissue enhanced (seminal vesicle)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, testis, seminal vesicle, epididymis, ovary, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle)

GENE INFORMATION

Gene name

 MCF2 (HGNC Symbol)

Synonyms

 ARHGEF21, DBL

Description

 MCF.2 cell line derived transforming sequence (HGNC Symbol)

Entrez gene summary

 The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010]

Chromosome

 X

Cytoband

 q27.1

Chromosome location (bp)

 139581770 - 139708227

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101977 (version 83.38)

Entrez gene

 4168

UniProt

 P10911 (UniProt - Evidence at protein level)

neXtProt

 NX_P10911

Antibodypedia

 MCF2 antibodies

PROTEIN BROWSER
MCF2-001
MCF2-002
MCF2-003
MCF2-004
MCF2-005
MCF2-006
MCF2-008
MCF2-201
MCF2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MCF2-001
ENSP00000427745
ENST00000520602
P10911 [Direct mapping]
Proto-oncogene DBL MCF2-transforming protein DBL-transforming protein
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 985 aa
114.4 kDa 		No 0
MCF2-002
ENSP00000359608
ENST00000370576
P10911 [Direct mapping]
Proto-oncogene DBL MCF2-transforming protein DBL-transforming protein
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 925 aa
107.7 kDa 		No 0
MCF2-003
ENSP00000359605
ENST00000370573
P10911 [Direct mapping]
Proto-oncogene DBL MCF2-transforming protein DBL-transforming protein
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 860 aa
100.4 kDa 		No 0
MCF2-004
ENSP00000342204
ENST00000338585
P10911 [Direct mapping]
Proto-oncogene DBL MCF2-transforming protein DBL-transforming protein
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 941 aa
109.4 kDa 		No 0
MCF2-005
ENSP00000405848
ENST00000446225
Q5JYJ5 [Direct mapping]
Proto-oncogene DBL
Show all
Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 528 aa
61.6 kDa 		No 0
MCF2-006
ENSP00000403271
ENST00000437564
H0Y662 [Direct mapping]
Proto-oncogene DBL
Show all
Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 429 aa
50.4 kDa 		No 0
MCF2-008
ENSP00000430276
ENST00000519895
P10911 [Direct mapping]
Proto-oncogene DBL MCF2-transforming protein DBL-transforming protein
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0016358 [dendrite development]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 1001 aa
116.1 kDa 		No 0
MCF2-201
ENSP00000397055
ENST00000414978
P10911 [Direct mapping]
Proto-oncogene DBL MCF2-transforming protein DBL-transforming protein
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 985 aa
114.4 kDa 		No 0
MCF2-202
ENSP00000438155
ENST00000536274
P10911 [Direct mapping]
Proto-oncogene DBL MCF2-transforming protein DBL-transforming protein
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 821 aa
95.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.