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RENBP

GENERAL INFORMATION

Gene name

 RENBP

Gene description

 Renin binding protein

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Distinct nuclear and cytoplasmic expression in kidney tubules and dendritic cells in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA000428 , HPA000522
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RENBP (HGNC Symbol)

Synonyms

 RBP, RNBP

Description

 Renin binding protein (HGNC Symbol)

Entrez gene summary

 The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 153935263 - 153944691

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102032 (version 83.38)

Entrez gene

 5973

UniProt

 P51606 (UniProt - Evidence at protein level)

neXtProt

 NX_P51606

Antibodypedia

 RENBP antibodies

PROTEIN BROWSER
RENBP-001
RENBP-003
RENBP-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RENBP-001
ENSP00000377303
ENST00000393700
P51606 [Direct mapping]
N-acylglucosamine 2-epimerase
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004857 [enzyme inhibitor activity]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005524 [ATP binding]
GO:0006044 [N-acetylglucosamine metabolic process]
GO:0006051 [N-acetylmannosamine metabolic process]
GO:0008217 [regulation of blood pressure]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0017076 [purine nucleotide binding]
GO:0019262 [N-acetylneuraminate catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0050121 [N-acylglucosamine 2-epimerase activity]
GO:0070062 [extracellular exosome]
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 427 aa
48.8 kDa 		No 0
RENBP-003
ENSP00000409034
ENST00000451114
H7C317 [Direct mapping]
N-acylglucosamine 2-epimerase
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0006044 [N-acetylglucosamine metabolic process]
GO:0006051 [N-acetylmannosamine metabolic process]
GO:0050121 [N-acylglucosamine 2-epimerase activity]
Show all
 125 aa
14.2 kDa 		No 0
RENBP-004
ENSP00000359014
ENST00000369997
A6NKZ2 [Direct mapping]
N-acylglucosamine 2-epimerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0006044 [N-acetylglucosamine metabolic process]
GO:0006051 [N-acetylmannosamine metabolic process]
GO:0050121 [N-acylglucosamine 2-epimerase activity]
Show all
 413 aa
47.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.