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SMARCA1

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GENERAL INFORMATION

Gene name

 SMARCA1

Gene description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to vesicles.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Vesicles (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA064712
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to vesicles.

Main location

 Nucleoplasm (supported)

Additional location

 Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA064712 Hep G2 Nucleoplasm
Vesicles
HPA064712 SH-SY5Y Nucleoplasm
HPA064712 U-2 OS Nucleoplasm
Vesicles

GENE INFORMATION

Gene name

 SMARCA1 (HGNC Symbol)

Synonyms

 hSNF2L, ISWI, NURF140, SNF2L, SNF2L1, SNF2LB, SWI

Description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 X

Cytoband

Chromosome location (bp)

 129446501 - 129523500

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102038 (version 83.38)

Entrez gene

 6594

UniProt

 P28370 (UniProt - Evidence at protein level)

neXtProt

 NX_P28370

Antibodypedia

 SMARCA1 antibodies

PROTEIN BROWSER
SMARCA1-004
SMARCA1-005
SMARCA1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMARCA1-004
ENSP00000360163
ENST00000371122
P28370 [Direct mapping]
Probable global transcription activator SNF2L1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000733 [DNA strand renaturation]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0007420 [brain development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0016589 [NURF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030182 [neuron differentiation]
GO:0031491 [nucleosome binding]
GO:0036310 [annealing helicase activity]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070615 [nucleosome-dependent ATPase activity]
GO:0090537 [CERF complex]
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 1054 aa
122.6 kDa 		No 0
SMARCA1-005
ENSP00000360162
ENST00000371121
B7ZLQ5 [Direct mapping]
Probable global transcription activator SNF2L1; SMARCA1 protein; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1, isoform CRA_d
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0008152 [metabolic process]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030182 [neuron differentiation]
GO:0031491 [nucleosome binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:2000177 [regulation of neural precursor cell proliferation]
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 1070 aa
124.3 kDa 		No 0
SMARCA1-006
ENSP00000360164
ENST00000371123
A0A0A0MRP6 [Direct mapping]
Probable global transcription activator SNF2L1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0008152 [metabolic process]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0031491 [nucleosome binding]
GO:0043044 [ATP-dependent chromatin remodeling]
Show all
 1058 aa
122.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.