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RBBP7

CANCER ATLAS

Gene description

 Retinoblastoma binding protein 7

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA060724
CAB037084

GENE INFORMATION

Gene name

 RBBP7 (HGNC Symbol)

Synonyms

 RbAp46

Description

 Retinoblastoma binding protein 7 (HGNC Symbol)

Entrez gene summary

 This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 16839283 - 16870414

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102054 (version 83.38)

Entrez gene

 5931

UniProt

 Q16576 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16576

Antibodypedia

 RBBP7 antibodies

PROTEIN BROWSER
RBBP7-002
RBBP7-004
RBBP7-006
RBBP7-007
RBBP7-008
RBBP7-010
RBBP7-012
RBBP7-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBBP7-002
ENSP00000402796
ENST00000444437
Q5JP02 [Direct mapping]
Histone-binding protein RBBP7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 175 aa
19.5 kDa 		No 0
RBBP7-004
ENSP00000392714
ENST00000416035
Q5JP01 [Direct mapping]
Histone-binding protein RBBP7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 285 aa
31.5 kDa 		No 0
RBBP7-006
ENSP00000369427
ENST00000380087
Q16576 [Direct mapping]
Histone-binding protein RBBP7
Q6FHQ0 [Target identity:100%; Query identity:100%]
RBBP7 protein; Retinoblastoma binding protein 7; Retinoblastoma binding protein 7, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0010467 [gene expression]
GO:0016581 [NuRD complex]
GO:0030308 [negative regulation of cell growth]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0070370 [cellular heat acclimation]
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 425 aa
47.8 kDa 		No 0
RBBP7-007
ENSP00000415747
ENST00000425696
Q5JNZ6 [Direct mapping]
Histone-binding protein RBBP7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 85 aa
9.5 kDa 		No 0
RBBP7-008
ENSP00000369424
ENST00000380084
Q16576 [Direct mapping]
Histone-binding protein RBBP7
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0010467 [gene expression]
GO:0016581 [NuRD complex]
GO:0030308 [negative regulation of cell growth]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048545 [response to steroid hormone]
GO:0070370 [cellular heat acclimation]
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 469 aa
52.3 kDa 		No 0
RBBP7-010
ENSP00000386068
ENST00000404022
E9PC52 [Direct mapping]
Histone-binding protein RBBP7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
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 416 aa
46.9 kDa 		No 0
RBBP7-012
ENSP00000417507
ENST00000493145
C9JAJ9 [Direct mapping]
Histone-binding protein RBBP7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 37 aa
4.5 kDa 		No 0
RBBP7-013
ENSP00000417791
ENST00000468092
C9J7L0 [Direct mapping]
Histone-binding protein RBBP7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 68 aa
7.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.