Tissue expression of SLC25A14 - Summary

GENERAL INFORMATION
Gene name	SLC25A14
Gene description	Solute carrier family 25 (mitochondrial carrier, brain), member 14
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (pituitary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION
Gene name	SLC25A14 (HGNC Symbol)
Synonyms	BMCP1, UCP5
Description	Solute carrier family 25 (mitochondrial carrier, brain), member 14 (HGNC Symbol)
Entrez gene summary	Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Uncoupling proteins separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. Uncoupling proteins facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	q26.1
Chromosome location (bp)	130339888 - 130373361
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102078 (version 83.38)
Entrez gene	9016
UniProt	O95258 (UniProt - Evidence at transcript level)
neXtProt	NX_O95258
Antibodypedia	SLC25A14 antibodies

PROTEIN BROWSER

SLC25A14-001	SLC25A14-002	SLC25A14-003	SLC25A14-004	SLC25A14-201	SLC25A14-202	SLC25A14-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A14-001 ENSP00000218197 ENST00000218197	O95258 [Direct mapping] Brain mitochondrial carrier protein 1 Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006839 [mitochondrial transport] GO:0009060 [aerobic respiration] GO:0015992 [proton transport] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	325 aa 36.2 kDa	Yes	0
SLC25A14-002 ENSP00000354455 ENST00000361980	O95258 [Direct mapping] Brain mitochondrial carrier protein 1 Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006839 [mitochondrial transport] GO:0009060 [aerobic respiration] GO:0015992 [proton transport] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	322 aa 36 kDa	Yes	0
SLC25A14-003 ENSP00000342797 ENST00000339231	O95258 [Direct mapping] Brain mitochondrial carrier protein 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006839 [mitochondrial transport] GO:0009060 [aerobic respiration] GO:0015992 [proton transport] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	353 aa 39.2 kDa	Yes	4
SLC25A14-004 ENSP00000402578 ENST00000424447	Q5JY88 [Direct mapping] Brain mitochondrial carrier protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	198 aa 21.9 kDa	Yes	0
SLC25A14-201 ENSP00000445225 ENST00000543953	F6SL11 [Direct mapping] Brain mitochondrial carrier protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006839 [mitochondrial transport] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] Show all	290 aa 32.4 kDa	No	0
SLC25A14-202 ENSP00000444642 ENST00000545805	O95258 [Direct mapping] Brain mitochondrial carrier protein 1 Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006839 [mitochondrial transport] GO:0009060 [aerobic respiration] GO:0015992 [proton transport] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	325 aa 36.2 kDa	Yes	0
SLC25A14-203 ENSP00000477981 ENST00000612248	O95258 [Direct mapping] Brain mitochondrial carrier protein 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006839 [mitochondrial transport] GO:0009060 [aerobic respiration] GO:0015992 [proton transport] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	353 aa 39.2 kDa	Yes	4