Expression of PIM2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Pim-2 proto-oncogene, serine/threonine kinase

Protein class

Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA000285

GENE INFORMATION
Gene name	PIM2
Synonyms
Description	Pim-2 proto-oncogene, serine/threonine kinase (HGNC Symbol)
Entrez gene summary	This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	48913182 - 48919024
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102096 (version 83.38)
Entrez gene	11040
UniProt	Q9P1W9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P1W9
Antibodypedia	PIM2 antibodies

PROTEIN BROWSER

PIM2-001	PIM2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIM2-001 ENSP00000365692 ENST00000376509	Q9P1W9 [Direct mapping] Serine/threonine-protein kinase pim-2 A0A024QYW7 [Target identity:100%; Query identity:100%] Pim-2 oncogene, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007140 [male meiosis] GO:0007346 [regulation of mitotic cell cycle] GO:0008283 [cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008637 [apoptotic mitochondrial changes] GO:0009615 [response to virus] GO:0010508 [positive regulation of autophagy] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0050821 [protein stabilization] Show all	311 aa 34.2 kDa	No	1
PIM2-002 ENSP00000410960 ENST00000442430	C9J8V9 [Direct mapping] Serine/threonine-protein kinase pim-2 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0046777 [protein autophosphorylation] Show all	145 aa 16.4 kDa	No	0