Expression of SLC35A2 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 35 (UDP-galactose transporter), member A2

Protein class

Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036087

GENE INFORMATION
Gene name	SLC35A2 (HGNC Symbol)
Synonyms	UGALT, UGAT, UGT, UGT1, UGT2, UGTL
Description	Solute carrier family 35 (UDP-galactose transporter), member A2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the nucleotide-sugar transporter family. The encoded protein is a multi-pass membrane protein. It transports UDP-galactose from the cytosol into Golgi vesicles, where it serves as a glycosyl donor for the generation of glycans. Mutations in this gene cause congenital disorder of glycosylation type IIm (CDG2M). Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	48903180 - 48911958
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102100 (version 83.38)
Entrez gene	7355
UniProt	P78381 (UniProt - Evidence at protein level)
neXtProt	NX_P78381
Antibodypedia	SLC35A2 antibodies

PROTEIN BROWSER

SLC35A2-001	SLC35A2-002	SLC35A2-003	SLC35A2-004	SLC35A2-005	SLC35A2-006	SLC35A2-007	SLC35A2-009	SLC35A2-010	SLC35A2-011	SLC35A2-012	SLC35A2-014	SLC35A2-015	SLC35A2-017	SLC35A2-018	SLC35A2-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC35A2-001 ENSP00000247138 ENST00000247138	P78381 [Direct mapping] UDP-galactose translocator Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006012 [galactose metabolic process] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015785 [UDP-galactose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	396 aa 41.3 kDa	No	8
SLC35A2-002 ENSP00000365704 ENST00000376521	P78381 [Direct mapping] UDP-galactose translocator Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006012 [galactose metabolic process] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015785 [UDP-galactose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	393 aa 41 kDa	No	8
SLC35A2-003 ENSP00000402726 ENST00000445167	P78381 [Direct mapping] UDP-galactose translocator Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005351 [sugar:proton symporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006012 [galactose metabolic process] GO:0008643 [carbohydrate transport] GO:0015785 [UDP-galactose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	242 aa 25.2 kDa	No	2
SLC35A2-004 ENSP00000365712 ENST00000376529	A6NFI1 [Direct mapping] UDP-galactose translocator Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] Show all	224 aa 23.4 kDa	No	2
SLC35A2-005 ENSP00000415518 ENST00000446885	C9JCV5 [Direct mapping] UDP-galactose translocator Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:1901679 [nucleotide transmembrane transport] Show all	176 aa 18.8 kDa	No	3
SLC35A2-006 ENSP00000365698 ENST00000376515	A6NKM8 [Direct mapping] UDP-galactose translocator Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] Show all	218 aa 23.5 kDa	No	2
SLC35A2-007 ENSP00000365695 ENST00000376512	A6NGW4 [Direct mapping] UDP-galactose translocator Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] Show all	163 aa 17.1 kDa	No	2
SLC35A2-009 ENSP00000478617 ENST00000616181	B4DE15 [Direct mapping] UDP-galactose translocator; cDNA FLJ53300, highly similar to UDP-galactose translocator Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:1901679 [nucleotide transmembrane transport] Show all	406 aa 42.2 kDa	No	8
SLC35A2-010 ENSP00000489089 ENST00000635015	B4DSH7 [Target identity:100%; Query identity:100%] cDNA FLJ59970, highly similar to UDP-galactose translocator Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0016021 [integral component of membrane] Show all	176 aa 18.3 kDa	No	2
SLC35A2-011 ENSP00000489197 ENST00000635589		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0016021 [integral component of membrane] Show all	332 aa 34.2 kDa	No	7
SLC35A2-012 ENSP00000416002 ENST00000452555	P78381 [Direct mapping] UDP-galactose translocator Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005459 [UDP-galactose transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006012 [galactose metabolic process] GO:0006810 [transport] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015785 [UDP-galactose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0072334 [UDP-galactose transmembrane transport] Show all	421 aa 44.1 kDa	No	8
SLC35A2-014 ENSP00000393233 ENST00000413561	P78381 [Direct mapping] UDP-galactose translocator Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005351 [sugar:proton symporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006012 [galactose metabolic process] GO:0008643 [carbohydrate transport] GO:0015785 [UDP-galactose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	202 aa 21.9 kDa	No	0
SLC35A2-015 ENSP00000489440 ENST00000634461		SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0016021 [integral component of membrane] Show all	102 aa 10.3 kDa	No	0
SLC35A2-017 ENSP00000489515 ENST00000635238		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0016021 [integral component of membrane] Show all	191 aa 20 kDa	Yes	3
SLC35A2-018 ENSP00000489356 ENST00000634665		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		114 aa 11.5 kDa	Yes	2
SLC35A2-019 ENSP00000489339 ENST00000635460		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0016021 [integral component of membrane] Show all	175 aa 18 kDa	No	2