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TAZ

CANCER ATLAS

Gene description

 Tafazzin

Protein class

 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA039557

GENE INFORMATION

Gene name

 TAZ (HGNC Symbol)

Synonyms

 BTHS, CMD3A, EFE, EFE2, G4.5, XAP-2

Description

 Tafazzin (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 154411518 - 154421726

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102125 (version 83.38)

Entrez gene

 6901

UniProt

 Q16635 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16635

Antibodypedia

 TAZ antibodies

PROTEIN BROWSER
TAZ-001
TAZ-002
TAZ-003
TAZ-004
TAZ-006
TAZ-011
TAZ-012
TAZ-027

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAZ-001
ENSP00000469981
ENST00000601016
Q16635 [Direct mapping]
Tafazzin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005829 [cytosol]
GO:0006644 [phospholipid metabolic process]
GO:0006936 [muscle contraction]
GO:0007507 [heart development]
GO:0007519 [skeletal muscle tissue development]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0030097 [hemopoiesis]
GO:0031224 [intrinsic component of membrane]
GO:0031966 [mitochondrial membrane]
GO:0032049 [cardiolipin biosynthetic process]
GO:0032981 [mitochondrial respiratory chain complex I assembly]
GO:0035965 [cardiolipin acyl-chain remodeling]
GO:0042407 [cristae formation]
GO:0042775 [mitochondrial ATP synthesis coupled electron transport]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0047184 [1-acylglycerophosphocholine O-acyltransferase activity]
GO:0048738 [cardiac muscle tissue development]
GO:0060048 [cardiac muscle contraction]
Show all
 292 aa
33.5 kDa 		No 1
TAZ-002
ENSP00000481037
ENST00000612460
Q16635 [Direct mapping]
Tafazzin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006936 [muscle contraction]
GO:0007507 [heart development]
GO:0007519 [skeletal muscle tissue development]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0030097 [hemopoiesis]
GO:0031224 [intrinsic component of membrane]
GO:0031966 [mitochondrial membrane]
GO:0032049 [cardiolipin biosynthetic process]
GO:0032981 [mitochondrial respiratory chain complex I assembly]
GO:0035965 [cardiolipin acyl-chain remodeling]
GO:0042407 [cristae formation]
GO:0042775 [mitochondrial ATP synthesis coupled electron transport]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0047184 [1-acylglycerophosphocholine O-acyltransferase activity]
GO:0048738 [cardiac muscle tissue development]
GO:0060048 [cardiac muscle contraction]
Show all
 262 aa
30.2 kDa 		No 1
TAZ-003
ENSP00000419854
ENST00000475699
Q16635 [Direct mapping]
Tafazzin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006936 [muscle contraction]
GO:0007507 [heart development]
GO:0007519 [skeletal muscle tissue development]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0030097 [hemopoiesis]
GO:0031224 [intrinsic component of membrane]
GO:0031966 [mitochondrial membrane]
GO:0032049 [cardiolipin biosynthetic process]
GO:0032981 [mitochondrial respiratory chain complex I assembly]
GO:0035965 [cardiolipin acyl-chain remodeling]
GO:0042407 [cristae formation]
GO:0042775 [mitochondrial ATP synthesis coupled electron transport]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0047184 [1-acylglycerophosphocholine O-acyltransferase activity]
GO:0048738 [cardiac muscle tissue development]
GO:0060048 [cardiac muscle contraction]
Show all
 278 aa
31.7 kDa 		No 1
TAZ-004
ENSP00000478154
ENST00000613002
Q16635 [Direct mapping]
Tafazzin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006936 [muscle contraction]
GO:0007507 [heart development]
GO:0007519 [skeletal muscle tissue development]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0030097 [hemopoiesis]
GO:0031224 [intrinsic component of membrane]
GO:0031966 [mitochondrial membrane]
GO:0032049 [cardiolipin biosynthetic process]
GO:0032981 [mitochondrial respiratory chain complex I assembly]
GO:0035965 [cardiolipin acyl-chain remodeling]
GO:0042407 [cristae formation]
GO:0042775 [mitochondrial ATP synthesis coupled electron transport]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0047184 [1-acylglycerophosphocholine O-acyltransferase activity]
GO:0048738 [cardiac muscle tissue development]
GO:0060048 [cardiac muscle contraction]
Show all
 248 aa
28.5 kDa 		No 1
TAZ-006
ENSP00000358791
ENST00000369776
Q96F92 [Direct mapping]
TAZ protein; Tafazzin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0031224 [intrinsic component of membrane]
GO:0031966 [mitochondrial membrane]
GO:0035965 [cardiolipin acyl-chain remodeling]
Show all
 262 aa
29 kDa 		No 1
TAZ-011
ENSP00000483636
ENST00000616020
A0A087X0T0 [Direct mapping]
Tafazzin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0031224 [intrinsic component of membrane]
GO:0031966 [mitochondrial membrane]
GO:0035965 [cardiolipin acyl-chain remodeling]
Show all
 170 aa
19.1 kDa 		No 0
TAZ-012
ENSP00000482070
ENST00000612012
A0A087WYT1 [Direct mapping]
Tafazzin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0031224 [intrinsic component of membrane]
GO:0031966 [mitochondrial membrane]
GO:0035965 [cardiolipin acyl-chain remodeling]
Show all
 196 aa
22.3 kDa 		No 0
TAZ-027
ENSP00000398193
ENST00000439735
C9J699 [Direct mapping]
Tafazzin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0031224 [intrinsic component of membrane]
GO:0031966 [mitochondrial membrane]
GO:0035965 [cardiolipin acyl-chain remodeling]
Show all
 184 aa
21.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.