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Cancer tissues displayed weak to moderate cytoplasmic staining with nuclear and membranous positivity in many cases. A single case of renal cancer and duct carcinoma of breast was strongly positive. Several cases of lymphomas, stomach, pancreatic, skin and cervical cancers were negative.
Most cancer cells displayed moderate to strong immunoreactivity in cytoplasm and nuclei. A majority of prostate, cervical and liver cancer were weakly stained or negative.
GENE INFORMATION
Gene name
PGK1
Synonyms
Description
Phosphoglycerate kinase 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
