Expression of MAGT1 in cancer - Summary

CANCER ATLAS

Gene description

Magnesium transporter 1

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA049851

GENE INFORMATION
Gene name	MAGT1 (HGNC Symbol)
Synonyms	DKFZp564K142, IAP, MRX95, OST3B
Description	Magnesium transporter 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband	q21.1
Chromosome location (bp)	77826364 - 77895593
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102158 (version 83.38)
Entrez gene	84061
UniProt	Q9H0U3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H0U3
Antibodypedia	MAGT1 antibodies

PROTEIN BROWSER

MAGT1-001	MAGT1-002	MAGT1-004	MAGT1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAGT1-001 ENSP00000354649 ENST00000358075	A0A087WU53 [Direct mapping] Magnesium transporter protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0016021 [integral component of membrane] GO:0045454 [cell redox homeostasis] Show all	367 aa 41.5 kDa	Yes	4
MAGT1-002 ENSP00000362433 ENST00000373336	Q9H0U3 [Direct mapping] Magnesium transporter protein 1 Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006487 [protein N-linked glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045454 [cell redox homeostasis] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	134 aa 15.7 kDa	Yes	0
MAGT1-004 ENSP00000480732 ENST00000618282	Q9H0U3 [Direct mapping] Magnesium transporter protein 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006487 [protein N-linked glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045454 [cell redox homeostasis] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	335 aa 38 kDa	Yes	4
MAGT1-201 ENSP00000478379 ENST00000610432	A0A087WU53 [Direct mapping] Magnesium transporter protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0016021 [integral component of membrane] GO:0045454 [cell redox homeostasis] Show all	367 aa 41.5 kDa	Yes	4