Expression of PCYT1B in cancer - Summary

CANCER ATLAS

Gene description

Phosphate cytidylyltransferase 1, choline, beta

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006367

GENE INFORMATION
Gene name	PCYT1B (HGNC Symbol)
Synonyms	CCT-beta, CTB
Description	Phosphate cytidylyltransferase 1, choline, beta (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Chromosome	X
Cytoband	p22.11
Chromosome location (bp)	24558087 - 24672677
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102230 (version 83.38)
Entrez gene	9468
UniProt	Q9Y5K3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5K3
Antibodypedia	PCYT1B antibodies

PROTEIN BROWSER

PCYT1B-003	PCYT1B-004	PCYT1B-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCYT1B-003 ENSP00000368440 ENST00000379145	Q9Y5K3 [Direct mapping] Choline-phosphate cytidylyltransferase B Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004105 [choline-phosphate cytidylyltransferase activity] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0006657 [CDP-choline pathway] GO:0009058 [biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	351 aa 40.2 kDa	No	0
PCYT1B-004 ENSP00000368439 ENST00000379144	Q9Y5K3 [Direct mapping] Choline-phosphate cytidylyltransferase B Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001541 [ovarian follicle development] GO:0003824 [catalytic activity] GO:0004105 [choline-phosphate cytidylyltransferase activity] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0006657 [CDP-choline pathway] GO:0007283 [spermatogenesis] GO:0009058 [biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	369 aa 41.9 kDa	No	0
PCYT1B-005 ENSP00000349211 ENST00000356768	Q9Y5K3 [Direct mapping] Choline-phosphate cytidylyltransferase B Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004105 [choline-phosphate cytidylyltransferase activity] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0006657 [CDP-choline pathway] GO:0009058 [biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	330 aa 38.1 kDa	No	0