Expression of GABRE in cancer - Summary

CANCER ATLAS

Gene description

Gamma-aminobutyric acid (GABA) A receptor, epsilon

Protein class

FDA approved drug targets, Predicted membrane proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045918

GENE INFORMATION
Gene name	GABRE
Synonyms
Description	Gamma-aminobutyric acid (GABA) A receptor, epsilon (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	151953124 - 151974680
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000102287 (version 83.38)
Entrez gene	2564
UniProt	P78334 (UniProt - Evidence at transcript level)
neXtProt	NX_P78334
Antibodypedia	GABRE antibodies

PROTEIN BROWSER

GABRE-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GABRE-001 ENSP00000359353 ENST00000370328	P78334 [Direct mapping] Gamma-aminobutyric acid receptor subunit epsilon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004890 [GABA-A receptor activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005237 [inhibitory extracellular ligand-gated ion channel activity] GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0008503 [benzodiazepine receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0034707 [chloride channel complex] GO:0042391 [regulation of membrane potential] GO:0042493 [response to drug] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0050877 [neurological system process] GO:1902476 [chloride transmembrane transport] GO:1902711 [GABA-A receptor complex] Show all	506 aa 58 kDa	Yes	4