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SRPX2

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GENERAL INFORMATION

Gene name

 SRPX2

Gene description

 Sushi-repeat containing protein, X-linked 2

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the microtubules.

RNA cell category

 Cell line enhanced (ASC TERT1, HUVEC TERT2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubules (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA038786
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, HUVEC TERT2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the microtubules.

Main location

 Microtubules (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA038786 A-431 Microtubules
HPA038786 U-2 OS Microtubules
HPA038786 U-251 MG Microtubules

GENE INFORMATION

Gene name

 SRPX2 (HGNC Symbol)

Synonyms

 SRPUL

Description

 Sushi-repeat containing protein, X-linked 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and mental retardation. [provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 q22.1

Chromosome location (bp)

 100644218 - 100671299

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102359 (version 83.38)

Entrez gene

 27286

UniProt

 O60687 (UniProt - Evidence at protein level)

neXtProt

 NX_O60687

Antibodypedia

 SRPX2 antibodies

PROTEIN BROWSER
SRPX2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRPX2-001
ENSP00000362095
ENST00000373004
O60687 [Direct mapping]
Sushi repeat-containing protein SRPX2
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0009986 [cell surface]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030054 [cell junction]
GO:0036458 [hepatocyte growth factor binding]
GO:0042325 [regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0048870 [cell motility]
GO:0051965 [positive regulation of synapse assembly]
GO:0060076 [excitatory synapse]
GO:0071625 [vocalization behavior]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0097060 [synaptic membrane]
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 465 aa
53 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.