Expression of GLA in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Galactosidase, alpha

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Carcinoid

STAINING SUMMARY

HPA000237	HPA000966

GENE INFORMATION
Gene name	GLA (HGNC Symbol)
Synonyms	GALA
Description	Galactosidase, alpha (HGNC Symbol)
Entrez gene summary	This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q22.1
Chromosome location (bp)	101397803 - 101407925
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102393 (version 83.38)
Entrez gene	2717
UniProt	P06280 (UniProt - Evidence at protein level)
neXtProt	NX_P06280
Antibodypedia	GLA antibodies

PROTEIN BROWSER

GLA-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLA-001 ENSP00000218516 ENST00000218516	P06280 [Direct mapping] Alpha-galactosidase A Q53Y83 [Target identity:100%; Query identity:100%] Galactosidase, alpha; Galactosidase, alpha, isoform CRA_a; cDNA FLJ76285, highly similar to Homo sapiens galactosidase, alpha (GLA), mRNA Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004557 [alpha-galactosidase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0009311 [oligosaccharide metabolic process] GO:0016139 [glycoside catabolic process] GO:0016787 [hydrolase activity] GO:0016936 [galactoside binding] GO:0042803 [protein homodimerization activity] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0045019 [negative regulation of nitric oxide biosynthetic process] GO:0046477 [glycosylceramide catabolic process] GO:0046479 [glycosphingolipid catabolic process] GO:0051001 [negative regulation of nitric-oxide synthase activity] GO:0052692 [raffinose alpha-galactosidase activity] GO:0070062 [extracellular exosome] Show all	429 aa 48.8 kDa	Yes	0