Cell atlas - ARMCX3 - The Human Protein Atlas

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ARMCX3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus
	Nucleoplasm

Human cell
	Cytosol
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ARMCX3
Gene description	Armadillo repeat containing, X-linked 3
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol & the Golgi apparatus.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Golgi apparatus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA000967 , HPA001530
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol & the Golgi apparatus.

Main location

Nucleoplasm (approved)

Additional location

Golgi apparatus (approved), Cytosol (approved)


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Antibody	Cell line	Location
HPA001530	A-431	Nucleoplasm
HPA001530	U-2 OS	Nucleoplasm
HPA001530	U-2 OS	Golgi apparatus
HPA001530	U-251 MG	Nucleoplasm
HPA001530	U-251 MG	Golgi apparatus
HPA000967	A-431	Nucleoplasm
HPA000967	A-431	Cytosol
HPA000967	U-2 OS	Nucleoplasm
HPA000967	U-2 OS	Cytosol
HPA000967	U-251 MG	Nucleoplasm
HPA000967	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ARMCX3 (HGNC Symbol)
Synonyms	ALEX3, GASP6
Description	Armadillo repeat containing, X-linked 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q22.1
Chromosome location (bp)	101622797 - 101627843
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102401 (version 83.38)
Entrez gene	51566
UniProt	Q9UH62 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UH62
Antibodypedia	ARMCX3 antibodies

PROTEIN BROWSER

ARMCX3-001	ARMCX3-003	ARMCX3-004	ARMCX3-006	ARMCX3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARMCX3-001 ENSP00000340672 ENST00000341189	Q9UH62 [Direct mapping] Armadillo repeat-containing X-linked protein 3 A0A024RCF9 [Target identity:100%; Query identity:100%] Armadillo repeat containing, X-linked 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0031307 [integral component of mitochondrial outer membrane] GO:0034613 [cellular protein localization] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	379 aa 42.5 kDa	No	1
ARMCX3-003 ENSP00000454251 ENST00000479298	H3BM63 [Direct mapping] Armadillo repeat-containing X-linked protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	63 aa 6.8 kDa	No	1
ARMCX3-004 ENSP00000454483 ENST00000471229	Q9UH62 [Direct mapping] Armadillo repeat-containing X-linked protein 3 A0A024RCF9 [Target identity:100%; Query identity:100%] Armadillo repeat containing, X-linked 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	379 aa 42.5 kDa	No	1
ARMCX3-006 ENSP00000457997 ENST00000491568	H3BV87 [Direct mapping] Armadillo repeat-containing X-linked protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	94 aa 10.2 kDa	No	1
ARMCX3-201 ENSP00000439032 ENST00000537169	Q9UH62 [Direct mapping] Armadillo repeat-containing X-linked protein 3 A0A024RCF9 [Target identity:100%; Query identity:100%] Armadillo repeat containing, X-linked 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	379 aa 42.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.