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HTR2A

GENERAL INFORMATION

Gene name

 HTR2A

Gene description

 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex)
FANTOM5:Group enriched (brain, caudate, hippocampus, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in CNS and peripheral ganglia.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA014011
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, hippocampus, retina)

GENE INFORMATION

Gene name

 HTR2A (HGNC Symbol)

Synonyms

 5-HT2A, HTR2

Description

 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 13

Cytoband

 q14.2

Chromosome location (bp)

 46831550 - 46897076

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102468 (version 83.38)

Entrez gene

 3356

UniProt

 P28223 (UniProt - Evidence at protein level)

neXtProt

 NX_P28223

Antibodypedia

 HTR2A antibodies

PROTEIN BROWSER
HTR2A-001
HTR2A-002
HTR2A-201
HTR2A-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HTR2A-001
ENSP00000367959
ENST00000378688
P28223 [Direct mapping]
5-hydroxytryptamine receptor 2A
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001618 [virus receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008144 [drug binding]
GO:0010513 [positive regulation of phosphatidylinositol biosynthetic process]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030424 [axon]
GO:0042493 [response to drug]
GO:0046718 [viral entry into host cell]
GO:0046883 [regulation of hormone secretion]
GO:0050795 [regulation of behavior]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051378 [serotonin binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071886 [1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding]
Show all
 471 aa
52.6 kDa 		No 7
HTR2A-002
ENSP00000482708
ENST00000612998
A0A087WZJ9 [Direct mapping]
5-hydroxytryptamine receptor 2A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0006939 [smooth muscle contraction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007210 [serotonin receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0043198 [dendritic shaft]
GO:0046883 [regulation of hormone secretion]
GO:0050795 [regulation of behavior]
Show all
 110 aa
12.1 kDa 		No 2
HTR2A-201
ENSP00000437737
ENST00000542664
P28223 [Direct mapping]
5-hydroxytryptamine receptor 2A
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001659 [temperature homeostasis]
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007208 [phospholipase C-activating serotonin receptor signaling pathway]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007568 [aging]
GO:0007613 [memory]
GO:0008144 [drug binding]
GO:0008219 [cell death]
GO:0008284 [positive regulation of cell proliferation]
GO:0010513 [positive regulation of phosphatidylinositol biosynthetic process]
GO:0014059 [regulation of dopamine secretion]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014824 [artery smooth muscle contraction]
GO:0014832 [urinary bladder smooth muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019233 [sensory perception of pain]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030431 [sleep]
GO:0032403 [protein complex binding]
GO:0033674 [positive regulation of kinase activity]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043198 [dendritic shaft]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044380 [protein localization to cytoskeleton]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045821 [positive regulation of glycolytic process]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046718 [viral entry into host cell]
GO:0046883 [regulation of hormone secretion]
GO:0048148 [behavioral response to cocaine]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050795 [regulation of behavior]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051378 [serotonin binding]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070852 [cell body fiber]
GO:0071886 [1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding]
Show all
 471 aa
52.6 kDa 		No 7
HTR2A-202
ENSP00000441861
ENST00000543956
P28223 [Direct mapping]
5-hydroxytryptamine receptor 2A
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008144 [drug binding]
GO:0010513 [positive regulation of phosphatidylinositol biosynthetic process]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030424 [axon]
GO:0042493 [response to drug]
GO:0046718 [viral entry into host cell]
GO:0046883 [regulation of hormone secretion]
GO:0050795 [regulation of behavior]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051378 [serotonin binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071886 [1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding]
Show all
 387 aa
43.9 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.