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This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007165 [signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0012501 [programmed cell death] GO:0016020 [membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0030336 [negative regulation of cell migration] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0042542 [response to hydrogen peroxide] GO:0042981 [regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0048679 [regulation of axon regeneration] GO:0070062 [extracellular exosome] GO:0097194 [execution phase of apoptosis]
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007165 [signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0012501 [programmed cell death] GO:0016020 [membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0030336 [negative regulation of cell migration] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0042542 [response to hydrogen peroxide] GO:0042981 [regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0048679 [regulation of axon regeneration] GO:0070062 [extracellular exosome] GO:0097194 [execution phase of apoptosis]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0007346 [regulation of mitotic cell cycle] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0042981 [regulation of apoptotic process]