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Fraction of cells in few renal cell carcinomas showed strong cytoplasmic positivity. Rare cases of melanoma and hepatocellular carcinoma exhibited weak immunoreactivity. Other cancer tissues were negative.
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001503 [ossification] GO:0003993 [acid phosphatase activity] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0007162 [negative regulation of cell adhesion] GO:0008198 [ferrous iron binding] GO:0008199 [ferric iron binding] GO:0010043 [response to zinc ion] GO:0014070 [response to organic cyclic compound] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016787 [hydrolase activity] GO:0030316 [osteoclast differentiation] GO:0030335 [positive regulation of cell migration] GO:0032496 [response to lipopolysaccharide] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032695 [negative regulation of interleukin-12 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0032929 [negative regulation of superoxide anion generation] GO:0033555 [multicellular organismal response to stress] GO:0033591 [response to L-ascorbic acid] GO:0034097 [response to cytokine] GO:0044281 [small molecule metabolic process] GO:0045019 [negative regulation of nitric oxide biosynthetic process] GO:0045453 [bone resorption] GO:0050728 [negative regulation of inflammatory response] GO:0050830 [defense response to Gram-positive bacterium] GO:0060349 [bone morphogenesis] GO:0070062 [extracellular exosome] GO:0070723 [response to cholesterol]
Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
