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ARHGEF7

GENERAL INFORMATION

Gene name

 ARHGEF7

Gene description

 Rho guanine nucleotide exchange factor (GEF) 7

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA004744
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARHGEF7 (HGNC Symbol)

Synonyms

 BETA-PIX, COOL1, DKFZp686C12170, DKFZp761K1021, KIAA0142, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB

Description

 Rho guanine nucleotide exchange factor (GEF) 7 (HGNC Symbol)

Entrez gene summary

 Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q34

Chromosome location (bp)

 111114559 - 111305737

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102606 (version 83.38)

Entrez gene

 8874

UniProt

 Q14155 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14155

Antibodypedia

 ARHGEF7 antibodies

PROTEIN BROWSER
«
ARHGEF7-001
ARHGEF7-003
ARHGEF7-004
ARHGEF7-005
ARHGEF7-007
ARHGEF7-008
ARHGEF7-009
ARHGEF7-011
ARHGEF7-013
ARHGEF7-015
ARHGEF7-016
ARHGEF7-018
ARHGEF7-201
ARHGEF7-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF7-001
ENSP00000218789
ENST00000218789
B1ALK7 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 705 aa
79.8 kDa 		No 0
ARHGEF7-003
ENSP00000406732
ENST00000449979
B1ANY6 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 66 aa
7.6 kDa 		No 0
ARHGEF7-004
ENSP00000397068
ENST00000426073
Q14155 [Direct mapping]
Rho guanine nucleotide exchange factor 7
A0A024RDY9 [Target identity:100%; Query identity:100%]
Rho guanine nucleotide exchange factor (GEF) 7, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0010763 [positive regulation of fibroblast migration]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1904424 [regulation of GTP binding]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 646 aa
73.1 kDa 		No 0
ARHGEF7-005
ENSP00000364875
ENST00000375723
Q14155 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0010763 [positive regulation of fibroblast migration]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1904424 [regulation of GTP binding]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 625 aa
70.4 kDa 		No 0
ARHGEF7-007
ENSP00000364888
ENST00000375736
Q14155 [Direct mapping]
Rho guanine nucleotide exchange factor 7
A0A024RDY9 [Target identity:100%; Query identity:100%]
Rho guanine nucleotide exchange factor (GEF) 7, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0010763 [positive regulation of fibroblast migration]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1904424 [regulation of GTP binding]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 646 aa
73.1 kDa 		No 0
ARHGEF7-008
ENSP00000325994
ENST00000317133
Q14155 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0010763 [positive regulation of fibroblast migration]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1904424 [regulation of GTP binding]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 782 aa
87.8 kDa 		No 0
ARHGEF7-009
ENSP00000389890
ENST00000426768
E7ENL8 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 143 aa
16 kDa 		No 0
ARHGEF7-011
ENSP00000417596
ENST00000478679
E9PDQ5 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 547 aa
61.6 kDa 		No 0
ARHGEF7-013
ENSP00000418067
ENST00000466143
E7EUY6 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 447 aa
50.5 kDa 		No 0
ARHGEF7-015
ENSP00000418043
ENST00000491775
C9JAD7 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 39 aa
4.5 kDa 		No 0
ARHGEF7-016
ENSP00000420592
ENST00000467053
C9JDI6 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 61 aa
7.1 kDa 		No 0
ARHGEF7-018
ENSP00000445384
ENST00000544132
F6SJA5 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 130 aa
14.5 kDa 		No 0
ARHGEF7-201
ENSP00000364891
ENST00000375739
Q14155 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0010763 [positive regulation of fibroblast migration]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1904424 [regulation of GTP binding]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 753 aa
84.5 kDa 		No 0
ARHGEF7-202
ENSP00000364893
ENST00000375741
Q14155 [Direct mapping]
Rho guanine nucleotide exchange factor 7
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000322 [storage vacuole]
GO:0001726 [ruffle]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0010763 [positive regulation of fibroblast migration]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0032092 [positive regulation of protein binding]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0060124 [positive regulation of growth hormone secretion]
GO:0097190 [apoptotic signaling pathway]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1904424 [regulation of GTP binding]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 803 aa
90 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.