Expression of MRPS31 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein S31

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039083	HPA046344

GENE INFORMATION
Gene name	MRPS31 (HGNC Symbol)
Synonyms	IMOGN38
Description	Mitochondrial ribosomal protein S31 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q14.11
Chromosome location (bp)	40729135 - 40771173
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102738 (version 83.38)
Entrez gene	10240
UniProt	Q92665 (UniProt - Evidence at protein level)
neXtProt	NX_Q92665
Antibodypedia	MRPS31 antibodies

PROTEIN BROWSER

MRPS31-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPS31-001 ENSP00000315397 ENST00000323563	Q92665 [Direct mapping] 28S ribosomal protein S31, mitochondrial Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005763 [mitochondrial small ribosomal subunit] GO:0006996 [organelle organization] GO:0019904 [protein domain specific binding] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	395 aa 45.3 kDa	No	0