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FLT1

GENERAL INFORMATION

Gene name

 FLT1

Gene description

 Fms-related tyrosine kinase 1

Protein class

 Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (placenta)
GTEx:Expressed in all
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in endothelial cells, smooth muscle and placental trophoblasts.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 4 antibodies.
HPA011740 , HPA014290 , CAB068189 , CAB068190
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 FLT1 (HGNC Symbol)

Synonyms

 FLT, VEGFR1

Description

 Fms-related tyrosine kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

Chromosome

 13

Cytoband

 q12.3

Chromosome location (bp)

 28300344 - 28495128

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102755 (version 83.38)

Entrez gene

 2321

UniProt

 P17948 (UniProt - Evidence at protein level)

neXtProt

 NX_P17948

Antibodypedia

 FLT1 antibodies

PROTEIN BROWSER
FLT1-001
FLT1-002
FLT1-003
FLT1-201
FLT1-202
FLT1-203
FLT1-204
FLT1-205

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FLT1-001
ENSP00000282397
ENST00000282397
P17948 [Direct mapping]
Vascular endothelial growth factor receptor 1
L7RSL3 [Target identity:100%; Query identity:100%]
Receptor protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001666 [response to hypoxia]
GO:0002548 [monocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019838 [growth factor binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030522 [intracellular receptor signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036323 [vascular endothelial growth factor receptor-1 signaling pathway]
GO:0036326 [VEGF-A-activated receptor activity]
GO:0036327 [VEGF-B-activated receptor activity]
GO:0036332 [placental growth factor-activated receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045766 [positive regulation of angiogenesis]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048514 [blood vessel morphogenesis]
GO:0048598 [embryonic morphogenesis]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
Show all
 1338 aa
150.8 kDa 		Yes 1
FLT1-002
ENSP00000484039
ENST00000615840
P17948 [Direct mapping]
Vascular endothelial growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019838 [growth factor binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036323 [vascular endothelial growth factor receptor-1 signaling pathway]
GO:0036326 [VEGF-A-activated receptor activity]
GO:0036327 [VEGF-B-activated receptor activity]
GO:0036332 [placental growth factor-activated receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045766 [positive regulation of angiogenesis]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048514 [blood vessel morphogenesis]
GO:0048598 [embryonic morphogenesis]
Show all
 687 aa
77.5 kDa 		Yes 0
FLT1-003
ENSP00000437631
ENST00000541932
P17948 [Direct mapping]
Vascular endothelial growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019838 [growth factor binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036323 [vascular endothelial growth factor receptor-1 signaling pathway]
GO:0036326 [VEGF-A-activated receptor activity]
GO:0036327 [VEGF-B-activated receptor activity]
GO:0036332 [placental growth factor-activated receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045766 [positive regulation of angiogenesis]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048514 [blood vessel morphogenesis]
GO:0048598 [embryonic morphogenesis]
Show all
 733 aa
82.1 kDa 		Yes 0
FLT1-201
ENSP00000442630
ENST00000539099
P17948 [Direct mapping]
Vascular endothelial growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019838 [growth factor binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036323 [vascular endothelial growth factor receptor-1 signaling pathway]
GO:0036326 [VEGF-A-activated receptor activity]
GO:0036327 [VEGF-B-activated receptor activity]
GO:0036332 [placental growth factor-activated receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045766 [positive regulation of angiogenesis]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048514 [blood vessel morphogenesis]
GO:0048598 [embryonic morphogenesis]
Show all
 541 aa
60.9 kDa 		Yes 0
FLT1-202
ENSP00000443311
ENST00000540678
H9N1E8 [Direct mapping]
Vascular endothelial growth factor receptor 1; p28FLT1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 85 aa
9.6 kDa 		No 0
FLT1-203
ENSP00000437841
ENST00000543394
P17948 [Direct mapping]
Vascular endothelial growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019838 [growth factor binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036323 [vascular endothelial growth factor receptor-1 signaling pathway]
GO:0036326 [VEGF-A-activated receptor activity]
GO:0036327 [VEGF-B-activated receptor activity]
GO:0036332 [placental growth factor-activated receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045766 [positive regulation of angiogenesis]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048514 [blood vessel morphogenesis]
GO:0048598 [embryonic morphogenesis]
Show all
 361 aa
41.2 kDa 		No 0
FLT1-204
ENSP00000484385
ENST00000615611
H9N1E7 [Direct mapping]
Vascular endothelial growth factor receptor 1; p19FLT1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 433 aa
49.4 kDa 		No 0
FLT1-205
ENSP00000484832
ENST00000617835
H9N1E8 [Direct mapping]
Vascular endothelial growth factor receptor 1; p28FLT1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 85 aa
9.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.