Tissue expression of INTS6 - Summary - The Human Protein Atlas

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INTS6

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TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	INTS6
Gene description	Integrator complex subunit 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA001552 , HPA001846
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	INTS6 (HGNC Symbol)
Synonyms	DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2
Description	Integrator complex subunit 6 (HGNC Symbol)
Entrez gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]
Chromosome	13
Cytoband	q14.3
Chromosome location (bp)	51354077 - 51454264
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102786 (version 83.38)
Entrez gene	26512
UniProt	Q9UL03 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UL03
Antibodypedia	INTS6 antibodies

PROTEIN BROWSER

INTS6-001	INTS6-003	INTS6-006	INTS6-007	INTS6-011	INTS6-013	INTS6-014	INTS6-016	INTS6-018	INTS6-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INTS6-001 ENSP00000310260 ENST00000311234	Q9UL03 [Direct mapping] Integrator complex subunit 6 A0A024RDU0 [Target identity:100%; Query identity:100%] Integrator complex subunit 6, isoform CRA_d Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0007165 [signal transduction] GO:0015629 [actin cytoskeleton] GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	887 aa 100.4 kDa	No	0
INTS6-003 ENSP00000411245 ENST00000442263	Q9UL03 [Direct mapping] Integrator complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0007165 [signal transduction] GO:0015629 [actin cytoskeleton] GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	115 aa 12.9 kDa	No	0
INTS6-006 ENSP00000419984 ENST00000490542	G5E9X1 [Direct mapping] Integrator complex subunit 6; Integrator complex subunit 6, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0015629 [actin cytoskeleton] Show all	571 aa 65.4 kDa	No	0
INTS6-007 ENSP00000381187 ENST00000398119	Q9UL03 [Direct mapping] Integrator complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0007165 [signal transduction] GO:0015629 [actin cytoskeleton] GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	874 aa 99 kDa	No	0
INTS6-011 ENSP00000419871 ENST00000497989	B3KQH5 [Direct mapping] Integrator complex subunit 6; Integrator complex subunit 6, isoform CRA_b; cDNA FLJ39377 fis, clone PERIC2000180, highly similar to Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 (DDX26), mRNA; cDNA FLJ45485 fis, clone BRTHA2002661, highly similar to Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 (DDX26), mRNA; cDNA FLJ90465 fis, clone NT2RP3002286, highly similar to Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 (DDX26), mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0015629 [actin cytoskeleton] Show all	709 aa 80.5 kDa	No	0
INTS6-013 ENSP00000417707 ENST00000483288	C9J885 [Direct mapping] Integrator complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 14 kDa	No	0
INTS6-014 ENSP00000419569 ENST00000485178	C9K0V7 [Direct mapping] Integrator complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 14.5 kDa	No	0
INTS6-016 ENSP00000419144 ENST00000488009	C9JXP6 [Direct mapping] Integrator complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 9.9 kDa	No	0
INTS6-018 ENSP00000419287 ENST00000491189	C9JVX2 [Direct mapping] Integrator complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 14.4 kDa	No	0
INTS6-020 ENSP00000418026 ENST00000483746	C9JAV7 [Direct mapping] Integrator complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		154 aa 17.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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