Tissue expression of IRG1 - Summary - The Human Protein Atlas

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IRG1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IRG1
Gene description	Immunoresponsive 1 homolog (mouse)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (appendix)
GTEx:	Not detected
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 1 antibody. HPA040143
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (appendix)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	IRG1
Synonyms
Description	Immunoresponsive 1 homolog (mouse) (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q22.3
Chromosome location (bp)	76948497 - 76958642
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102794 (version 83.38)
Entrez gene	730249
UniProt	A6NK06 (UniProt - Evidence at protein level)
neXtProt	NX_A6NK06
Antibodypedia	IRG1 antibodies

PROTEIN BROWSER

IRG1-001	IRG1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IRG1-001 ENSP00000366682 ENST00000377462	A6NK06 [Direct mapping] Cis-aconitate decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Show all	GO:0002760 [positive regulation of antimicrobial humoral response] GO:0005739 [mitochondrion] GO:0006952 [defense response] GO:0006954 [inflammatory response] GO:0007566 [embryo implantation] GO:0008152 [metabolic process] GO:0016829 [lyase activity] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032480 [negative regulation of type I interferon production] GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0035458 [cellular response to interferon-beta] GO:0045824 [negative regulation of innate immune response] GO:0047613 [aconitate decarboxylase activity] GO:0050728 [negative regulation of inflammatory response] GO:0071219 [cellular response to molecule of bacterial origin] GO:0071222 [cellular response to lipopolysaccharide] GO:0071346 [cellular response to interferon-gamma] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071393 [cellular response to progesterone stimulus] GO:0072573 [tolerance induction to lipopolysaccharide] GO:2000379 [positive regulation of reactive oxygen species metabolic process] Show all	481 aa 52.6 kDa	No	0
IRG1-201 ENSP00000401584 ENST00000449753	H7C1Q4 [Direct mapping] Cis-aconitate decarboxylase Show all	Predicted intracellular proteins Show all	GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016829 [lyase activity] Show all	481 aa 52.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.