Cell atlas - TSC22D1 - The Human Protein Atlas

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TSC22D1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TSC22D1
Gene description	TSC22 domain family, member 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies & nucleoplasm.
RNA cell category	Cell line enhanced (HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA077414
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies & nucleoplasm.

Main location

Nucleoplasm (approved), Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA077414	A549	Nucleoplasm
	HPA077414	CACO-2	Nucleoplasm
	HPA077414	CACO-2	Nuclear bodies
	HPA077414	U-2 OS	Nucleoplasm
	HPA077414	U-2 OS	Nuclear bodies

GENE INFORMATION
Gene name	TSC22D1 (HGNC Symbol)
Synonyms	MGC17597, TGFB1I4, TSC22
Description	TSC22 domain family, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Chromosome	13
Cytoband	q14.11
Chromosome location (bp)	44432143 - 44577147
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102804 (version 83.38)
Entrez gene	8848
UniProt	Q15714 (UniProt - Evidence at protein level)
neXtProt	NX_Q15714
Antibodypedia	TSC22D1 antibodies

PROTEIN BROWSER

TSC22D1-001	TSC22D1-002	TSC22D1-008	TSC22D1-009	TSC22D1-201	TSC22D1-202	TSC22D1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSC22D1-001 ENSP00000397435 ENST00000458659	Q15714 [Direct mapping] TSC22 domain family protein 1 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008284 [positive regulation of cell proliferation] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] Show all	1073 aa 109.7 kDa	No	0
TSC22D1-002 ENSP00000261489 ENST00000261489	Q15714 [Direct mapping] TSC22 domain family protein 1 A0A024RDV8 [Target identity:100%; Query identity:100%] TSC22 domain family, member 1, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] Show all	144 aa 15.7 kDa	No	0
TSC22D1-008 ENSP00000418739 ENST00000493016	C9IZ15 [Direct mapping] TSC22 domain family protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	142 aa 14.2 kDa	No	0
TSC22D1-009 ENSP00000419864 ENST00000472477	C9JYW3 [Direct mapping] TSC22 domain family protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	41 aa 4.7 kDa	No	0
TSC22D1-201 ENSP00000437414 ENST00000501704	Q15714 [Direct mapping] TSC22 domain family protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] Show all	570 aa 58.9 kDa	No	0
TSC22D1-202 ENSP00000481585 ENST00000611198	A0A087X0H8 [Direct mapping] TSC22 domain family protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	86 aa 9.4 kDa	No	0
TSC22D1-203 ENSP00000483407 ENST00000622051	A0A087X0H8 [Direct mapping] TSC22 domain family protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	86 aa 9.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.