Tissue expression of HSF4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HSF4
Gene description	Heat shock transcription factor 4
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	HSF4 (HGNC Symbol)
Synonyms	CTM
Description	Heat shock transcription factor 4 (HGNC Symbol)
Entrez gene summary	Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	67164681 - 67169945
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102878 (version 83.38)
Entrez gene	3299
UniProt	Q9ULV5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULV5
Antibodypedia	HSF4 antibodies

PROTEIN BROWSER

HSF4-001	HSF4-006	HSF4-012	HSF4-018	HSF4-024	HSF4-026	HSF4-027	HSF4-028

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSF4-001 ENSP00000463706 ENST00000584272	Q9ULV5 [Direct mapping] Heat shock factor protein 4 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0019903 [protein phosphatase binding] GO:0043565 [sequence-specific DNA binding] Show all	462 aa 50 kDa	No	0
HSF4-006 ENSP00000430947 ENST00000521374	Q9ULV5 [Direct mapping] Heat shock factor protein 4 A0A024R6X7 [Target identity:100%; Query identity:100%] HCG2025835, isoform CRA_a; HCG2040102, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001654 [eye development] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008284 [positive regulation of cell proliferation] GO:0019903 [protein phosphatase binding] GO:0033169 [histone H3-K9 demethylation] GO:0043010 [camera-type eye development] GO:0043565 [sequence-specific DNA binding] GO:0045597 [positive regulation of cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048468 [cell development] GO:0051260 [protein homooligomerization] GO:0070207 [protein homotrimerization] Show all	492 aa 53 kDa	No	0
HSF4-012 ENSP00000428978 ENST00000517685	E5RK26 [Direct mapping] Heat shock factor protein 4 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] Show all	416 aa 45.2 kDa	No	0
HSF4-018 ENSP00000428077 ENST00000519601	H0YAU2 [Direct mapping] Heat shock factor protein 4 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	224 aa 23.3 kDa	No	0
HSF4-024 ENSP00000429486 ENST00000521916	H0YBG9 [Direct mapping] Heat shock factor protein 4 Show all	Predicted intracellular proteins Show all		63 aa 6.4 kDa	No	0
HSF4-026 ENSP00000430299 ENST00000517729	H0YBT7 [Direct mapping] Heat shock factor protein 4 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] Show all	185 aa 21 kDa	No	0
HSF4-027 ENSP00000430211 ENST00000517750	H0YBS6 [Direct mapping] Heat shock factor protein 4 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	183 aa 19.5 kDa	No	0
HSF4-028 ENSP00000430840 ENST00000520304	H0YC39 [Direct mapping] Heat shock factor protein 4 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	141 aa 15 kDa	No	0