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NFAT5

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GENERAL INFORMATION

Gene name

 NFAT5

Gene description

 Nuclear factor of activated T-cells 5, tonicity-responsive

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Additional location

 In addition localized to the Cytosol (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA057304 , HPA069711
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

 Nucleus (supported)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA057304 A549 Nucleoplasm
HPA057304 Hep G2 Nucleoplasm
Cytosol
HPA057304 U-2 OS Nucleoplasm
HPA069711 RT4 Nucleoplasm
HPA069711 SiHa Nucleus Intensity
HPA069711 U-2 OS Nucleus

GENE INFORMATION

Gene name

 NFAT5 (HGNC Symbol)

Synonyms

 KIAA0827, NF-AT5, NFATL1, NFATZ, OREBP, TONEBP

Description

 Nuclear factor of activated T-cells 5, tonicity-responsive (HGNC Symbol)

Entrez gene summary

 The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 69565094 - 69704666

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102908 (version 83.38)

Entrez gene

 10725

UniProt

 O94916 (UniProt - Evidence at protein level)

neXtProt

 NX_O94916

Antibodypedia

 NFAT5 antibodies

PROTEIN BROWSER
NFAT5-001
NFAT5-002
NFAT5-006
NFAT5-007
NFAT5-009
NFAT5-012
NFAT5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFAT5-001
ENSP00000346420
ENST00000354436
O94916 [Direct mapping]
Nuclear factor of activated T-cells 5
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007588 [excretion]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 1531 aa
165.8 kDa 		No 0
NFAT5-002
ENSP00000377343
ENST00000393742
O94916 [Direct mapping]
Nuclear factor of activated T-cells 5
A0A024R734 [Target identity:100%; Query identity:100%]
Nuclear factor of activated T-cells 5, tonicity-responsive, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007588 [excretion]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 1455 aa
158 kDa 		No 0
NFAT5-006
ENSP00000455628
ENST00000566899
O94916 [Direct mapping]
Nuclear factor of activated T-cells 5
A0A024R734 [Target identity:100%; Query identity:100%]
Nuclear factor of activated T-cells 5, tonicity-responsive, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007588 [excretion]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 1455 aa
158 kDa 		No 0
NFAT5-007
ENSP00000463214
ENST00000565301
J3QKS5 [Direct mapping]
Nuclear factor of-activated T-cells 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 141 aa
14.7 kDa 		No 0
NFAT5-009
ENSP00000457593
ENST00000567239
O94916 [Direct mapping]
Nuclear factor of activated T-cells 5
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007588 [excretion]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 1548 aa
167.7 kDa 		No 0
NFAT5-012
ENSP00000486610
ENST00000627621
O94916 [Direct mapping]
Nuclear factor of activated T-cells 5
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001816 [cytokine production]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006970 [response to osmotic stress]
GO:0007165 [signal transduction]
GO:0007588 [excretion]
GO:0010628 [positive regulation of gene expression]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070884 [regulation of calcineurin-NFAT signaling cascade]
Show all
 1549 aa
167.8 kDa 		No 0
NFAT5-201
ENSP00000338806
ENST00000349945
O94916 [Direct mapping]
Nuclear factor of activated T-cells 5
A0A024R734 [Target identity:100%; Query identity:100%]
Nuclear factor of activated T-cells 5, tonicity-responsive, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007588 [excretion]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 1455 aa
158 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.