Cell atlas - CBLN1 - The Human Protein Atlas

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CBLN1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	CBLN1
Gene description	Cerebellin 1 precursor
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Group enriched (SCLC-21H, NTERA-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA056335
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Endoplasmic reticulum (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056335	SH-SY5Y	Endoplasmic reticulum

GENE INFORMATION
Gene name	CBLN1
Synonyms
Description	Cerebellin 1 precursor (HGNC Symbol)
Entrez gene summary	This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008]
Chromosome	16
Cytoband	q12.1
Chromosome location (bp)	49277917 - 49281831
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102924 (version 83.38)
Entrez gene	869
UniProt	P23435 (UniProt - Evidence at protein level)
neXtProt	NX_P23435
Antibodypedia	CBLN1 antibodies

PROTEIN BROWSER

CBLN1-001	CBLN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CBLN1-001 ENSP00000219197 ENST00000219197	P23435 [Direct mapping] Cerebellin-1 Cerebellin [des-Ser1]-cerebellin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005623 [cell] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0009306 [protein secretion] GO:0021707 [cerebellar granule cell differentiation] GO:0030054 [cell junction] GO:0042803 [protein homodimerization activity] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0051965 [positive regulation of synapse assembly] Show all	193 aa 21.1 kDa	Yes	0
CBLN1-201 ENSP00000444651 ENST00000536749	P23435 [Direct mapping] Cerebellin-1 Cerebellin [des-Ser1]-cerebellin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0021707 [cerebellar granule cell differentiation] GO:0030054 [cell junction] GO:0045211 [postsynaptic membrane] Show all	193 aa 21.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.