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CCL17

GENERAL INFORMATION

Gene name

 CCL17

Gene description

 Chemokine (C-C motif) ligand 17

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix, lymph node)
GTEx:Tissue enhanced (lung, small intestine)
FANTOM5:Group enriched (appendix, lung, tonsil, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues and in immune cells.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 1 antibody.
CAB002583
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, lung, tonsil, lymph node)

GENE INFORMATION

Gene name

 CCL17 (HGNC Symbol)

Synonyms

 ABCD-2, SCYA17, TARC

Description

 Chemokine (C-C motif) ligand 17 (HGNC Symbol)

Entrez gene summary

 This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

Chromosome

 16

Cytoband

 q21

Chromosome location (bp)

 57404767 - 57416062

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102970 (version 83.38)

Entrez gene

 6361

UniProt

 Q92583 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92583

Antibodypedia

 CCL17 antibodies

PROTEIN BROWSER
CCL17-001
CCL17-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL17-001
ENSP00000219244
ENST00000219244
Q92583 [Direct mapping]
C-C motif chemokine 17
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005102 [receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0008009 [chemokine activity]
GO:0030593 [neutrophil chemotaxis]
GO:0043547 [positive regulation of GTPase activity]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0048020 [CCR chemokine receptor binding]
GO:0048247 [lymphocyte chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 94 aa
10.5 kDa 		Yes 0
CCL17-201
ENSP00000480147
ENST00000616880
Q92583 [Direct mapping]
C-C motif chemokine 17
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005102 [receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0008009 [chemokine activity]
GO:0030593 [neutrophil chemotaxis]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048247 [lymphocyte chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 94 aa
10.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.