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ACD

CANCER ATLAS

Gene description

 Adrenocortical dysplasia homolog (mouse)

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057660

GENE INFORMATION

Gene name

 ACD (HGNC Symbol)

Synonyms

 Pip1, Ptop, Tint1, Tpp1

Description

 Adrenocortical dysplasia homolog (mouse) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 67657512 - 67660815

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102977 (version 83.38)

Entrez gene

 65057

UniProt

 Q96AP0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96AP0

Antibodypedia

 ACD antibodies

PROTEIN BROWSER
ACD-001
ACD-002
ACD-003
ACD-012
ACD-014
ACD-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACD-001
ENSP00000377496
ENST00000393919
Q96AP0 [Direct mapping]
Adrenocortical dysplasia protein homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006886 [intracellular protein transport]
GO:0016233 [telomere capping]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0032202 [telomere assembly]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0051973 [positive regulation of telomerase activity]
GO:0060381 [positive regulation of single-stranded telomeric DNA binding]
GO:0070182 [DNA polymerase binding]
GO:0070187 [telosome]
GO:0070198 [protein localization to chromosome, telomeric region]
Show all
 544 aa
57.7 kDa 		No 0
ACD-002
ENSP00000219251
ENST00000219251
Q96AP0 [Direct mapping]
Adrenocortical dysplasia protein homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006886 [intracellular protein transport]
GO:0016233 [telomere capping]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0032202 [telomere assembly]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0051973 [positive regulation of telomerase activity]
GO:0060381 [positive regulation of single-stranded telomeric DNA binding]
GO:0070182 [DNA polymerase binding]
GO:0070187 [telosome]
GO:0070198 [protein localization to chromosome, telomeric region]
Show all
 541 aa
57.4 kDa 		No 0
ACD-003
ENSP00000473679
ENST00000602320
R4GNJ5 [Direct mapping]
Adrenocortical dysplasia protein homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000783 [nuclear telomere cap complex]
GO:0032202 [telomere assembly]
Show all
 442 aa
47.1 kDa 		No 0
ACD-012
ENSP00000473313
ENST00000602382
R4GMR6 [Direct mapping]
Adrenocortical dysplasia protein homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000783 [nuclear telomere cap complex]
GO:0032202 [telomere assembly]
Show all
 182 aa
18.9 kDa 		No 0
ACD-014
ENSP00000478084
ENST00000620761
A0A0C4DGT6 [Direct mapping]
Adrenocortical dysplasia protein homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000783 [nuclear telomere cap complex]
GO:0032202 [telomere assembly]
Show all
 458 aa
49 kDa 		No 0
ACD-201
ENSP00000483117
ENST00000620338
Q96AP0 [Direct mapping]
Adrenocortical dysplasia protein homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0001501 [skeletal system development]
GO:0001655 [urogenital system development]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006886 [intracellular protein transport]
GO:0016233 [telomere capping]
GO:0030326 [embryonic limb morphogenesis]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0032202 [telomere assembly]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0035282 [segmentation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060381 [positive regulation of single-stranded telomeric DNA binding]
GO:0070182 [DNA polymerase binding]
GO:0070187 [telosome]
GO:0070198 [protein localization to chromosome, telomeric region]
Show all
 544 aa
57.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.