Fields »
ABOUT
HELP
BLOG
PARD6A

CANCER ATLAS

Gene description

 Par-6 family cell polarity regulator alpha

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041551
CAB009733

GENE INFORMATION

Gene name

 PARD6A (HGNC Symbol)

Synonyms

 PAR-6, PAR-6A, PAR6alpha, TAX40, TIP-40

Description

 Par-6 family cell polarity regulator alpha (HGNC Symbol)

Entrez gene summary

 This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 67660946 - 67662778

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102981 (version 83.38)

Entrez gene

 50855

UniProt

 Q9NPB6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPB6

Antibodypedia

 PARD6A antibodies

PROTEIN BROWSER
PARD6A-001
PARD6A-002
PARD6A-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PARD6A-001
ENSP00000219255
ENST00000219255
Q9NPB6 [Direct mapping]
Partitioning defective 6 homolog alpha
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0001726 [ruffle]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0017048 [Rho GTPase binding]
GO:0030742 [GTP-dependent protein binding]
GO:0034329 [cell junction assembly]
GO:0043025 [neuronal cell body]
GO:0043234 [protein complex]
GO:0044295 [axonal growth cone]
GO:0045177 [apical part of cell]
GO:0045216 [cell-cell junction organization]
GO:0045217 [cell-cell junction maintenance]
GO:0051301 [cell division]
GO:0060341 [regulation of cellular localization]
GO:0070830 [bicellular tight junction assembly]
Show all
 346 aa
37.4 kDa 		No 0
PARD6A-002
ENSP00000392388
ENST00000458121
Q9NPB6 [Direct mapping]
Partitioning defective 6 homolog alpha
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0007049 [cell cycle]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0017048 [Rho GTPase binding]
GO:0030742 [GTP-dependent protein binding]
GO:0034329 [cell junction assembly]
GO:0045216 [cell-cell junction organization]
GO:0045217 [cell-cell junction maintenance]
GO:0051301 [cell division]
GO:0070830 [bicellular tight junction assembly]
Show all
 345 aa
37.3 kDa 		No 0
PARD6A-004
ENSP00000473257
ENST00000602551
R4GMM2 [Direct mapping]
Partitioning defective 6 homolog alpha
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 316 aa
34.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.