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HAS3

CANCER ATLAS

Gene description

 Hyaluronan synthase 3

Protein class

 Enzymes, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA031554
CAB033850

GENE INFORMATION

Gene name

 HAS3

Synonyms

Description

 Hyaluronan synthase 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 69105564 - 69118719

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103044 (version 83.38)

Entrez gene

 3038

UniProt

 O00219 (UniProt - Evidence at transcript level)

neXtProt

 NX_O00219

Antibodypedia

 HAS3 antibodies

PROTEIN BROWSER
HAS3-001
HAS3-002
HAS3-003
HAS3-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HAS3-001
ENSP00000304440
ENST00000306560
O00219 [Direct mapping]
Hyaluronan synthase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0036117 [hyaluranon cable]
GO:0044281 [small molecule metabolic process]
GO:0045226 [extracellular polysaccharide biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050501 [hyaluronan synthase activity]
GO:0085029 [extracellular matrix assembly]
GO:1900106 [positive regulation of hyaluranon cable assembly]
Show all
 553 aa
63 kDa 		No 7
HAS3-002
ENSP00000219322
ENST00000219322
O00219 [Direct mapping]
Hyaluronan synthase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0036117 [hyaluranon cable]
GO:0044281 [small molecule metabolic process]
GO:0045226 [extracellular polysaccharide biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050501 [hyaluronan synthase activity]
GO:0085029 [extracellular matrix assembly]
GO:1900106 [positive regulation of hyaluranon cable assembly]
Show all
 281 aa
31.2 kDa 		No 2
HAS3-003
ENSP00000454731
ENST00000569188
O00219 [Direct mapping]
Hyaluronan synthase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0036117 [hyaluranon cable]
GO:0044281 [small molecule metabolic process]
GO:0045226 [extracellular polysaccharide biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050501 [hyaluronan synthase activity]
GO:0085029 [extracellular matrix assembly]
GO:1900106 [positive regulation of hyaluranon cable assembly]
Show all
 553 aa
63 kDa 		No 7
HAS3-004
ENSP00000456246
ENST00000566118
H3BRH5 [Direct mapping]
Hyaluronan synthase 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
GO:0030213 [hyaluronan biosynthetic process]
GO:0045226 [extracellular polysaccharide biosynthetic process]
GO:0050501 [hyaluronan synthase activity]
GO:0085029 [extracellular matrix assembly]
Show all
 264 aa
29.6 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.