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NME4

GENERAL INFORMATION

Gene name

 NME4

Gene description

 NME/NM23 nucleoside diphosphate kinase 4

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB045997
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NME4 (HGNC Symbol)

Synonyms

 NDPKD, nm23-H4, NM23H4

Description

 NME/NM23 nucleoside diphosphate kinase 4 (HGNC Symbol)

Entrez gene summary

 The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 396725 - 410367

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103202 (version 83.38)

Entrez gene

 4833

UniProt

 O00746 (UniProt - Evidence at protein level)

neXtProt

 NX_O00746

Antibodypedia

 NME4 antibodies

PROTEIN BROWSER
NME4-001
NME4-002
NME4-005
NME4-009
NME4-010
NME4-011
NME4-201
NME4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NME4-001
ENSP00000219479
ENST00000219479
O00746 [Direct mapping]
Nucleoside diphosphate kinase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0009116 [nucleoside metabolic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0042981 [regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 187 aa
20.7 kDa 		No 0
NME4-002
ENSP00000380834
ENST00000397722
O00746 [Direct mapping]
Nucleoside diphosphate kinase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0009116 [nucleoside metabolic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0042981 [regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 117 aa
13 kDa 		No 0
NME4-005
ENSP00000406317
ENST00000454619
A2IDC9 [Direct mapping]
Nucleoside diphosphate kinase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0042981 [regulation of apoptotic process]
Show all
 37 aa
4.3 kDa 		No 0
NME4-009
ENSP00000405925
ENST00000433358
H0Y6J0 [Direct mapping]
Nucleoside diphosphate kinase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0042981 [regulation of apoptotic process]
Show all
 169 aa
18.6 kDa 		No 0
NME4-010
ENSP00000389048
ENST00000450036
O00746 [Direct mapping]
Nucleoside diphosphate kinase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0009116 [nucleoside metabolic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0042981 [regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 117 aa
13 kDa 		No 0
NME4-011
ENSP00000372398
ENST00000382940
Q4TT34 [Direct mapping]
Nucleoside diphosphate kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0042981 [regulation of apoptotic process]
Show all
 195 aa
21.5 kDa 		No 0
NME4-201
ENSP00000479996
ENST00000620944
O00746 [Direct mapping]
Nucleoside diphosphate kinase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0009116 [nucleoside metabolic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0042981 [regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 117 aa
13 kDa 		No 0
NME4-202
ENSP00000479681
ENST00000621774
A0A087WVT9 [Direct mapping]
Nucleoside diphosphate kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0042981 [regulation of apoptotic process]
Show all
 153 aa
16.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.