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Most cancer tissues displayed moderate to strong cytoplasmic positivity. A majority of malignant gliomas and renal cancers were negative.
GENE INFORMATION
Gene name
FBXO31 (HGNC Symbol)
Synonyms
FBX14, Fbx31, FBXO14, MGC15419
Description
F-box protein 31 (HGNC Symbol)
Entrez gene summary
This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014)
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GO:0005515 [protein binding] GO:0006974 [cellular response to DNA damage stimulus] GO:0008054 [negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0030332 [cyclin binding] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0043025 [neuronal cell body]