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STUB1

CANCER ATLAS

Gene description

 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA041222
HPA043531
CAB037202
CAB037209

GENE INFORMATION

Gene name

 STUB1 (HGNC Symbol)

Synonyms

 CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1

Description

 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 680224 - 682870

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103266 (version 83.38)

Entrez gene

 10273

UniProt

 Q9UNE7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNE7

Antibodypedia

 STUB1 antibodies

PROTEIN BROWSER
STUB1-001
STUB1-002
STUB1-004
STUB1-008
STUB1-010
STUB1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STUB1-001
ENSP00000219548
ENST00000219548
Q9UNE7 [Direct mapping]
E3 ubiquitin-protein ligase CHIP
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0001664 [G-protein coupled receptor binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006515 [misfolded or incompletely synthesized protein catabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030544 [Hsp70 protein binding]
GO:0030579 [ubiquitin-dependent SMAD protein catabolic process]
GO:0030674 [protein binding, bridging]
GO:0030911 [TPR domain binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031371 [ubiquitin conjugating enzyme complex]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031943 [regulation of glucocorticoid metabolic process]
GO:0032091 [negative regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0036503 [ERAD pathway]
GO:0042405 [nuclear inclusion body]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046332 [SMAD binding]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0051604 [protein maturation]
GO:0051787 [misfolded protein binding]
GO:0051865 [protein autoubiquitination]
GO:0051879 [Hsp90 protein binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070534 [protein K63-linked ubiquitination]
GO:0071218 [cellular response to misfolded protein]
GO:0090035 [positive regulation of chaperone-mediated protein complex assembly]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
Show all
 303 aa
34.9 kDa 		No 0
STUB1-002
ENSP00000457228
ENST00000565677
Q9UNE7 [Direct mapping]
E3 ubiquitin-protein ligase CHIP
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0001664 [G-protein coupled receptor binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006515 [misfolded or incompletely synthesized protein catabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030544 [Hsp70 protein binding]
GO:0030579 [ubiquitin-dependent SMAD protein catabolic process]
GO:0030674 [protein binding, bridging]
GO:0030911 [TPR domain binding]
GO:0031371 [ubiquitin conjugating enzyme complex]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031943 [regulation of glucocorticoid metabolic process]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0036503 [ERAD pathway]
GO:0042405 [nuclear inclusion body]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046332 [SMAD binding]
GO:0051604 [protein maturation]
GO:0051787 [misfolded protein binding]
GO:0051865 [protein autoubiquitination]
GO:0051879 [Hsp90 protein binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070534 [protein K63-linked ubiquitination]
GO:0071218 [cellular response to misfolded protein]
GO:0090035 [positive regulation of chaperone-mediated protein complex assembly]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
Show all
 231 aa
27.1 kDa 		No 0
STUB1-004
ENSP00000456591
ENST00000567173
H3BS86 [Direct mapping]
E3 ubiquitin-protein ligase CHIP
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 214 aa
24.5 kDa 		No 0
STUB1-008
ENSP00000456875
ENST00000564370
Q9UNE7 [Direct mapping]
E3 ubiquitin-protein ligase CHIP
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0001664 [G-protein coupled receptor binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006515 [misfolded or incompletely synthesized protein catabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030544 [Hsp70 protein binding]
GO:0030579 [ubiquitin-dependent SMAD protein catabolic process]
GO:0030674 [protein binding, bridging]
GO:0030911 [TPR domain binding]
GO:0031371 [ubiquitin conjugating enzyme complex]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031943 [regulation of glucocorticoid metabolic process]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0036503 [ERAD pathway]
GO:0042405 [nuclear inclusion body]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046332 [SMAD binding]
GO:0051604 [protein maturation]
GO:0051787 [misfolded protein binding]
GO:0051865 [protein autoubiquitination]
GO:0051879 [Hsp90 protein binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070534 [protein K63-linked ubiquitination]
GO:0071218 [cellular response to misfolded protein]
GO:0090035 [positive regulation of chaperone-mediated protein complex assembly]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
Show all
 231 aa
27.1 kDa 		No 0
STUB1-010
ENSP00000457583
ENST00000566408
H3BUD0 [Direct mapping]
E3 ubiquitin-protein ligase CHIP
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0016567 [protein ubiquitination]
Show all
 185 aa
21.4 kDa 		No 0
STUB1-011
ENSP00000457090
ENST00000564316
H3BTA3 [Direct mapping]
E3 ubiquitin-protein ligase CHIP
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
Show all
 157 aa
18.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.