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The majority of cancer tissues showed weak to moderate cytoplasmic staining with additional nuclear positivity in many cases. Several hepatocellular carcinomas along with a few colorectal and ovarian cancers were strongly stained.
Lymphomas, gliomas and skin cancers along with several cases of melanomas, lung and urothelial cancers were negative.
This gene encodes a protein similar to Rhomboid in Drosophila which is involved in signalling in the Spitz/epidermal growth factor receptor/mitogen-activated protein kinase pathway. The Rhomboid family of proteins consists of intramembrane serine proteases containing several transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
