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UBE2I

CANCER ATLAS

Gene description

 Ubiquitin-conjugating enzyme E2I

Protein class

 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA003909
CAB009021

GENE INFORMATION

Gene name

 UBE2I (HGNC Symbol)

Synonyms

 UBC9

Description

 Ubiquitin-conjugating enzyme E2I (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 1308880 - 1327018

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103275 (version 83.38)

Entrez gene

 7329

UniProt

 P63279 (UniProt - Evidence at protein level)

neXtProt

 NX_P63279

Antibodypedia

 UBE2I antibodies

PROTEIN BROWSER
UBE2I-001
UBE2I-002
UBE2I-003
UBE2I-004
UBE2I-006
UBE2I-007
UBE2I-008
UBE2I-012
UBE2I-014
UBE2I-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2I-001
ENSP00000380649
ENST00000397514
P63279 [Direct mapping]
SUMO-conjugating enzyme UBC9
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000795 [synaptonemal complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0019899 [enzyme binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0061656 [SUMO conjugating enzyme activity]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071535 [RING-like zinc finger domain binding]
GO:1903755 [positive regulation of SUMO transferase activity]
GO:1990234 [transferase complex]
GO:1990356 [sumoylated E2 ligase complex]
Show all
 158 aa
18 kDa 		No 0
UBE2I-002
ENSP00000348056
ENST00000355803
P63279 [Direct mapping]
SUMO-conjugating enzyme UBC9
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000795 [synaptonemal complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0019899 [enzyme binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043398 [HLH domain binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0061656 [SUMO conjugating enzyme activity]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071535 [RING-like zinc finger domain binding]
GO:1903755 [positive regulation of SUMO transferase activity]
GO:1990234 [transferase complex]
GO:1990356 [sumoylated E2 ligase complex]
Show all
 158 aa
18 kDa 		No 0
UBE2I-003
ENSP00000324897
ENST00000325437
P63279 [Direct mapping]
SUMO-conjugating enzyme UBC9
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000795 [synaptonemal complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0019899 [enzyme binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0061656 [SUMO conjugating enzyme activity]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071535 [RING-like zinc finger domain binding]
GO:1903755 [positive regulation of SUMO transferase activity]
GO:1990234 [transferase complex]
GO:1990356 [sumoylated E2 ligase complex]
Show all
 158 aa
18 kDa 		No 0
UBE2I-004
ENSP00000380650
ENST00000397515
P63279 [Direct mapping]
SUMO-conjugating enzyme UBC9
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000795 [synaptonemal complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0019899 [enzyme binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0061656 [SUMO conjugating enzyme activity]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071535 [RING-like zinc finger domain binding]
GO:1903755 [positive regulation of SUMO transferase activity]
GO:1990234 [transferase complex]
GO:1990356 [sumoylated E2 ligase complex]
Show all
 158 aa
18 kDa 		No 0
UBE2I-006
ENSP00000384361
ENST00000402301
B0QYN7 [Direct mapping]
SUMO-conjugating enzyme UBC9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
Show all
 184 aa
20.5 kDa 		No 0
UBE2I-007
ENSP00000385009
ENST00000403747
P63279 [Direct mapping]
SUMO-conjugating enzyme UBC9
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000795 [synaptonemal complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0019899 [enzyme binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0061656 [SUMO conjugating enzyme activity]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071535 [RING-like zinc finger domain binding]
GO:1903755 [positive regulation of SUMO transferase activity]
GO:1990234 [transferase complex]
GO:1990356 [sumoylated E2 ligase complex]
Show all
 158 aa
18 kDa 		No 0
UBE2I-008
ENSP00000384568
ENST00000406620
P63279 [Direct mapping]
SUMO-conjugating enzyme UBC9
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000795 [synaptonemal complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0019899 [enzyme binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0061656 [SUMO conjugating enzyme activity]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071535 [RING-like zinc finger domain binding]
GO:1903755 [positive regulation of SUMO transferase activity]
GO:1990234 [transferase complex]
GO:1990356 [sumoylated E2 ligase complex]
Show all
 158 aa
18 kDa 		No 0
UBE2I-012
ENSP00000456188
ENST00000567383
H3BRD1 [Direct mapping]
SUMO-conjugating enzyme UBC9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016567 [protein ubiquitination]
Show all
 29 aa
3.3 kDa 		No 0
UBE2I-014
ENSP00000457064
ENST00000566587
P63279 [Direct mapping]
SUMO-conjugating enzyme UBC9
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000795 [synaptonemal complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0019899 [enzyme binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0061656 [SUMO conjugating enzyme activity]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071535 [RING-like zinc finger domain binding]
GO:1903755 [positive regulation of SUMO transferase activity]
GO:1990234 [transferase complex]
GO:1990356 [sumoylated E2 ligase complex]
Show all
 158 aa
18 kDa 		No 0
UBE2I-016
ENSP00000455893
ENST00000567074
H3BQQ9 [Direct mapping]
SUMO-conjugating enzyme UBC9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
Show all
 137 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.