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Testicular cancers, a few cases of colorectal, gastric, prostate, pancreatic, a few liver and ovarian cancers showed moderate cytoplasmic and nuclear positivity. Remaining cancer cells were weakly stained or negative.
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Enzymes ENZYME proteins Ligase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004818 [glutamate-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006424 [glutamyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] GO:0050561 [glutamate-tRNA(Gln) ligase activity] GO:0070127 [tRNA aminoacylation for mitochondrial protein translation]
Enzymes ENZYME proteins Ligase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004818 [glutamate-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006424 [glutamyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] GO:0050561 [glutamate-tRNA(Gln) ligase activity] GO:0070127 [tRNA aminoacylation for mitochondrial protein translation]
Enzymes ENZYME proteins Ligase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004818 [glutamate-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006424 [glutamyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] GO:0050561 [glutamate-tRNA(Gln) ligase activity] GO:0070127 [tRNA aminoacylation for mitochondrial protein translation]
