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TCEB2

GENERAL INFORMATION

Gene name

 TCEB2

Gene description

 Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TCEB2 (HGNC Symbol)

Synonyms

 SIII

Description

 Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) (HGNC Symbol)

Entrez gene summary

 This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 2771414 - 2777297

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103363 (version 83.38)

Entrez gene

 6923

UniProt

 Q15370 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15370

Antibodypedia

 TCEB2 antibodies

PROTEIN BROWSER
TCEB2-001
TCEB2-002
TCEB2-003
TCEB2-004
TCEB2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCEB2-001
ENSP00000386652
ENST00000409906
Q15370 [Direct mapping]
Transcription elongation factor B polypeptide 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0030891 [VCB complex]
GO:0031462 [Cul2-RING ubiquitin ligase complex]
GO:0031466 [Cul5-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0050434 [positive regulation of viral transcription]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070062 [extracellular exosome]
GO:0070449 [elongin complex]
GO:0071456 [cellular response to hypoxia]
Show all
 118 aa
13.1 kDa 		No 0
TCEB2-002
ENSP00000262306
ENST00000262306
Q15370 [Direct mapping]
Transcription elongation factor B polypeptide 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0030891 [VCB complex]
GO:0031462 [Cul2-RING ubiquitin ligase complex]
GO:0031466 [Cul5-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0050434 [positive regulation of viral transcription]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070062 [extracellular exosome]
GO:0070449 [elongin complex]
GO:0071456 [cellular response to hypoxia]
Show all
 161 aa
17.9 kDa 		No 0
TCEB2-003
ENSP00000387189
ENST00000409477
B8ZZU8 [Direct mapping]
Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B), isoform CRA_b; Transcription elongation factor B polypeptide 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0006414 [translational elongation]
GO:0030891 [VCB complex]
GO:0070449 [elongin complex]
Show all
 113 aa
12.5 kDa 		No 0
TCEB2-004
ENSP00000458213
ENST00000494946
I3L0M9 [Direct mapping]
Transcription elongation factor B polypeptide 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030891 [VCB complex]
GO:0070449 [elongin complex]
Show all
 140 aa
15.6 kDa 		No 0
TCEB2-005
ENSP00000458443
ENST00000572954
A0A0B4J296 [Direct mapping]
Transcription elongation factor B polypeptide 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030891 [VCB complex]
GO:0070449 [elongin complex]
Show all
 66 aa
7.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.