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AQP8

GENERAL INFORMATION

Gene name

 AQP8

Gene description

 Aquaporin 8

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (colon, pancreas, rectum)
GTEx:Group enriched (pancreas, colon)
FANTOM5:Tissue enriched (pancreas)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in colon, rectum and pancreas.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA046259
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, pancreas, rectum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pancreas, colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pancreas)

GENE INFORMATION

Gene name

 AQP8

Synonyms

Description

 Aquaporin 8 (HGNC Symbol)

Entrez gene summary

 Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p12.1

Chromosome location (bp)

 25215731 - 25228940

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103375 (version 83.38)

Entrez gene

 343

UniProt

 O94778 (UniProt - Evidence at transcript level)

neXtProt

 NX_O94778

Antibodypedia

 AQP8 antibodies

PROTEIN BROWSER
AQP8-001
AQP8-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AQP8-001
ENSP00000219660
ENST00000219660
O94778 [Direct mapping]
Aquaporin-8
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0000302 [response to reactive oxygen species]
GO:0005215 [transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0009992 [cellular water homeostasis]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0045177 [apical part of cell]
GO:0055085 [transmembrane transport]
GO:0071320 [cellular response to cAMP]
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 261 aa
27.4 kDa 		No 7
AQP8-002
ENSP00000454457
ENST00000566125
A0A0C4DGL6 [Direct mapping]
Aquaporin-8
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005623 [cell]
GO:0006810 [transport]
GO:0009992 [cellular water homeostasis]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
Show all
 255 aa
26.8 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.