Cell atlas - MTFMT - The Human Protein Atlas

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MTFMT

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MTFMT
Gene description	Mitochondrial methionyl-tRNA formyltransferase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040710
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040710	A-431	Nucleoplasm
	HPA040710	A-431	Cytosol
	HPA040710	U-2 OS	Nucleoplasm
	HPA040710	U-2 OS	Cytosol
	HPA040710	U-251 MG	Nucleoplasm
	HPA040710	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MTFMT (HGNC Symbol)
Synonyms	FMT1
Description	Mitochondrial methionyl-tRNA formyltransferase (HGNC Symbol)
Entrez gene summary	The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	65001512 - 65029639
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103707 (version 83.38)
Entrez gene	123263
UniProt	Q96DP5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96DP5
Antibodypedia	MTFMT antibodies

PROTEIN BROWSER

MTFMT-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTFMT-001 ENSP00000220058 ENST00000220058	Q96DP5 [Direct mapping] Methionyl-tRNA formyltransferase, mitochondrial Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004479 [methionyl-tRNA formyltransferase activity] GO:0005739 [mitochondrion] GO:0006996 [organelle organization] GO:0009058 [biosynthetic process] GO:0016742 [hydroxymethyl-, formyl- and related transferase activity] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0071951 [conversion of methionyl-tRNA to N-formyl-methionyl-tRNA] Show all	389 aa 43.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.