Fields »
ABOUT
HELP
BLOG
AP3B2

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 AP3B2

Gene description

 Adaptor-related protein complex 3, beta 2 subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the cytosol & nucleoplasm.

RNA cell category

 Cell line enhanced (SCLC-21H, SH-SY5Y, RT4)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (uncertain)

Additional location

 In addition localized to the Nucleoplasm (uncertain), Cytosol (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA039818
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, SH-SY5Y, RT4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the cytosol & nucleoplasm.

Main location

 Golgi apparatus (uncertain)

Additional location

 Nucleoplasm (uncertain), Cytosol (uncertain)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA039818 A-431 Nucleoplasm
Golgi apparatus
Cytosol
HPA039818 U-2 OS Nucleoplasm
Golgi apparatus
Cytosol
HPA039818 U-251 MG Nucleoplasm
Golgi apparatus
Cytosol

GENE INFORMATION

Gene name

 AP3B2 (HGNC Symbol)

Synonyms

 NAPTB

Description

 Adaptor-related protein complex 3, beta 2 subunit (HGNC Symbol)

Entrez gene summary

 Adaptor protein-3 (AP3) is a heterotetrameric vesicle-coat protein complex. Some AP3 subunits are ubiquitously expressed, whereas others are expressed exclusively in neurons. The neuron-specific AP3 complex, which includes AP3B2, is thought to serve neuron-specific functions such as neurotransmitter release (Grabner et al., 2006 [PubMed 16788073]).[supplied by OMIM, Mar 2008]

Chromosome

 15

Cytoband

 q25.2

Chromosome location (bp)

 82659281 - 82709914

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103723 (version 83.38)

Entrez gene

 8120

UniProt

 Q13367 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13367

Antibodypedia

 AP3B2 antibodies

PROTEIN BROWSER
AP3B2-001
AP3B2-002
AP3B2-003
AP3B2-004
AP3B2-011
AP3B2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP3B2-001
ENSP00000261722
ENST00000261722
Q13367 [Direct mapping]
AP-3 complex subunit beta-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008089 [anterograde axon cargo transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0030123 [AP-3 adaptor complex]
GO:0030137 [COPI-coated vesicle]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0048490 [anterograde synaptic vesicle transport]
Show all
 1082 aa
119.1 kDa 		No 0
AP3B2-002
ENSP00000440984
ENST00000535359
Q13367 [Direct mapping]
AP-3 complex subunit beta-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008089 [anterograde axon cargo transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0030123 [AP-3 adaptor complex]
GO:0030137 [COPI-coated vesicle]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0048490 [anterograde synaptic vesicle transport]
Show all
 1101 aa
121.2 kDa 		No 0
AP3B2-003
ENSP00000438721
ENST00000535348
Q13367 [Direct mapping]
AP-3 complex subunit beta-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008089 [anterograde axon cargo transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0030123 [AP-3 adaptor complex]
GO:0030137 [COPI-coated vesicle]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0048490 [anterograde synaptic vesicle transport]
Show all
 1050 aa
115.3 kDa 		No 0
AP3B2-004
ENSP00000440719
ENST00000542200
F5GYB0 [Direct mapping]
AP-3 complex subunit beta-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 141 aa
15.5 kDa 		No 0
AP3B2-011
ENSP00000441961
ENST00000541693
F5GWU4 [Direct mapping]
AP-3 complex subunit beta-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 193 aa
21.7 kDa 		No 0
AP3B2-201
ENSP00000479229
ENST00000620652
Q13367 [Direct mapping]
AP-3 complex subunit beta-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008089 [anterograde axon cargo transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0030123 [AP-3 adaptor complex]
GO:0030137 [COPI-coated vesicle]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0048490 [anterograde synaptic vesicle transport]
Show all
 1082 aa
119.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.