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Most cancers showed moderate to strong granular cytoplasmic positivity. Gliomas, melanomas, skin and testis cancers were generally weakly stained or negative.
GENE INFORMATION
Gene name
CTSH (HGNC Symbol)
Synonyms
ACC-4, ACC-5, ACC4, ACC5, CPSB
Description
Cathepsin H (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]