Cell atlas - CD276 - The Human Protein Atlas

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CD276

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	CD276
Gene description	CD276 molecule
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (U-2197)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA017139
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017139	A-431	Vesicles
	HPA017139	U-2 OS	Vesicles
	HPA017139	U-251 MG	Vesicles

GENE INFORMATION
Gene name	CD276 (HGNC Symbol)
Synonyms	B7-H3, B7H3, B7RP-2
Description	CD276 molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	15
Cytoband	q24.1
Chromosome location (bp)	73683966 - 73714518
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103855 (version 83.38)
Entrez gene	80381
UniProt	Q5ZPR3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5ZPR3
Antibodypedia	CD276 antibodies

PROTEIN BROWSER

CD276-001	CD276-002	CD276-003	CD276-007	CD276-012	CD276-014	CD276-015	CD276-016	CD276-017	CD276-018	CD276-020	CD276-021	CD276-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD276-001 ENSP00000454940 ENST00000564751	Q5ZPR3 [Direct mapping] CD276 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0008283 [cell proliferation] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0042102 [positive regulation of T cell proliferation] GO:0042110 [T cell activation] GO:0045078 [positive regulation of interferon-gamma biosynthetic process] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	316 aa 33.8 kDa	Yes	1
CD276-002 ENSP00000320084 ENST00000318443	Q5ZPR3 [Direct mapping] CD276 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0008283 [cell proliferation] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0030501 [positive regulation of bone mineralization] GO:0042102 [positive regulation of T cell proliferation] GO:0042110 [T cell activation] GO:0042130 [negative regulation of T cell proliferation] GO:0045077 [negative regulation of interferon-gamma biosynthetic process] GO:0045078 [positive regulation of interferon-gamma biosynthetic process] GO:0045085 [negative regulation of interleukin-2 biosynthetic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0050728 [negative regulation of inflammatory response] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] GO:1900042 [positive regulation of interleukin-2 secretion] Show all	534 aa 57.2 kDa	Yes	1
CD276-003 ENSP00000452736 ENST00000561213	Q5ZPR3 [Direct mapping] CD276 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0008283 [cell proliferation] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0042102 [positive regulation of T cell proliferation] GO:0042110 [T cell activation] GO:0045078 [positive regulation of interferon-gamma biosynthetic process] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	533 aa 57.2 kDa	Yes	1
CD276-007 ENSP00000441087 ENST00000537340	A0A0C4DGH0 [Direct mapping] CD276 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	388 aa 41.8 kDa	No	1
CD276-012 ENSP00000453014 ENST00000561176	H0YL10 [Direct mapping] CD276 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	199 aa 21.3 kDa	No	1
CD276-014 ENSP00000453907 ENST00000558689	H0YN85 [Direct mapping] CD276 antigen Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	136 aa 14.5 kDa	Yes	0
CD276-015 ENSP00000452669 ENST00000561260	H0YK59 [Direct mapping] CD276 antigen Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	165 aa 17.6 kDa	Yes	0
CD276-016 ENSP00000453336 ENST00000560995	H0YLT8 [Direct mapping] CD276 antigen Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	133 aa 14.2 kDa	Yes	0
CD276-017 ENSP00000452905 ENST00000561416	H0YKQ9 [Direct mapping] CD276 antigen Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.2 kDa	Yes	0
CD276-018 ENSP00000455366 ENST00000567189	H0YLT8 [Direct mapping] CD276 antigen Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	133 aa 14.2 kDa	Yes	0
CD276-020 ENSP00000454258 ENST00000563584	H3BM68 [Direct mapping] CD276 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	146 aa 15.7 kDa	No	1
CD276-021 ENSP00000452649 ENST00000560786	H0YK40 [Direct mapping] CD276 antigen Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	156 aa 16.7 kDa	Yes	0
CD276-201 ENSP00000320058 ENST00000318424	Q5ZPR3 [Direct mapping] CD276 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0008283 [cell proliferation] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0042102 [positive regulation of T cell proliferation] GO:0042110 [T cell activation] GO:0045078 [positive regulation of interferon-gamma biosynthetic process] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	316 aa 33.8 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.