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CEP152

GENERAL INFORMATION

Gene name

 CEP152

Gene description

 Centrosomal protein 152kDa

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, most abundant in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039408
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 CEP152 (HGNC Symbol)

Synonyms

 KIAA0912, MCPH4, SCKL5

Description

 Centrosomal protein 152kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Chromosome

 15

Cytoband

 q21.1

Chromosome location (bp)

 48712928 - 48811146

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103995 (version 83.38)

Entrez gene

 22995

UniProt

 O94986 (UniProt - Evidence at protein level)

neXtProt

 NX_O94986

Antibodypedia

 CEP152 antibodies

PROTEIN BROWSER
CEP152-001
CEP152-003
CEP152-004
CEP152-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CEP152-001
ENSP00000370337
ENST00000380950
O94986 [Direct mapping]
Centrosomal protein of 152 kDa
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007099 [centriole replication]
GO:0019901 [protein kinase binding]
GO:0030030 [cell projection organization]
GO:0051298 [centrosome duplication]
GO:0098535 [de novo centriole assembly]
GO:0098536 [deuterosome]
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 1710 aa
195.6 kDa 		No 0
CEP152-003
ENSP00000321000
ENST00000325747
O94986 [Direct mapping]
Centrosomal protein of 152 kDa
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007099 [centriole replication]
GO:0019901 [protein kinase binding]
GO:0030030 [cell projection organization]
GO:0051298 [centrosome duplication]
GO:0098535 [de novo centriole assembly]
GO:0098536 [deuterosome]
Show all
 1275 aa
147.3 kDa 		No 0
CEP152-004
ENSP00000382271
ENST00000399334
O94986 [Direct mapping]
Centrosomal protein of 152 kDa
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007099 [centriole replication]
GO:0019901 [protein kinase binding]
GO:0030030 [cell projection organization]
GO:0051298 [centrosome duplication]
GO:0098535 [de novo centriole assembly]
GO:0098536 [deuterosome]
Show all
 1654 aa
189.1 kDa 		No 0
CEP152-007
ENSP00000453914
ENST00000558591
H0YN91 [Direct mapping]
Centrosomal protein of 152 kDa
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005815 [microtubule organizing center]
GO:0007099 [centriole replication]
GO:0098535 [de novo centriole assembly]
GO:0098536 [deuterosome]
Show all
 68 aa
7.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.