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GABPB1

GENERAL INFORMATION

Gene name

 GABPB1

Gene description

 GA binding protein transcription factor, beta subunit 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA019653
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GABPB1 (HGNC Symbol)

Synonyms

 E4TF1-47, GABPB, GABPB2

Description

 GA binding protein transcription factor, beta subunit 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 50275392 - 50355408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104064 (version 83.38)

Entrez gene

 2553

UniProt

 Q06547 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06547

Antibodypedia

 GABPB1 antibodies

PROTEIN BROWSER
GABPB1-001
GABPB1-002
GABPB1-004
GABPB1-005
GABPB1-006
GABPB1-007
GABPB1-008
GABPB1-009
GABPB1-012
GABPB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GABPB1-001
ENSP00000370259
ENST00000380877
Q06547 [Direct mapping]
GA-binding protein subunit beta-1
A0A024R5X6 [Target identity:100%; Query identity:100%]
GA binding protein transcription factor, beta subunit 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 383 aa
41.3 kDa 		No 0
GABPB1-002
ENSP00000379728
ENST00000396464
Q06547 [Direct mapping]
GA-binding protein subunit beta-1
A0A024R5R5 [Target identity:100%; Query identity:100%]
GA binding protein transcription factor, beta subunit 2, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 348 aa
36.9 kDa 		No 0
GABPB1-004
ENSP00000395771
ENST00000429662
Q06547 [Direct mapping]
GA-binding protein subunit beta-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 360 aa
38.1 kDa 		No 0
GABPB1-005
ENSP00000220429
ENST00000220429
Q06547 [Direct mapping]
GA-binding protein subunit beta-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 395 aa
42.5 kDa 		No 0
GABPB1-006
ENSP00000442500
ENST00000543881
F5H7I4 [Direct mapping]
GA-binding protein subunit beta-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 319 aa
34.2 kDa 		No 0
GABPB1-007
ENSP00000453463
ENST00000560825
H9ZYI9 [Direct mapping]
GA binding protein transcription factor beta subunit 1 transcript variant gamma-2; GA binding protein transcription factor, beta subunit 2, isoform CRA_c; GA-binding protein subunit beta-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 347 aa
36.9 kDa 		No 0
GABPB1-008
ENSP00000454211
ENST00000558970
H0YNZ0 [Direct mapping]
GA-binding protein subunit beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 89 aa
9.6 kDa 		No 0
GABPB1-009
ENSP00000453578
ENST00000558335
H0YNZ0 [Direct mapping]
GA-binding protein subunit beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 89 aa
9.6 kDa 		No 0
GABPB1-012
ENSP00000453806
ENST00000561010
H0YMZ5 [Direct mapping]
GA-binding protein subunit beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 203 aa
20.9 kDa 		No 0
GABPB1-201
ENSP00000351923
ENST00000359031
Q06547 [Direct mapping]
GA-binding protein subunit beta-1
A0A024R5R5 [Target identity:100%; Query identity:100%]
GA binding protein transcription factor, beta subunit 2, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 348 aa
36.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.